Company to advance SZN-1326 toward first-in-human clinical studies in 2022
SOUTH SAN FRANCISCO, CA, USA I July 09, 2021 I Surrozen Inc., a biotechnology company discovering and developing drug candidates to selectively modulate the Wnt pathway, announced today that new data from its inflammatory bowel disease (IBD) program, including preclinical studies of SZN-1326 showing superior activity compared to therapeutics currently used in treatment, were presented during the 16th Congress of the European Crohn’s and Colitis Organisation.
Two poster presentations discussed data from studies of SZN-1326, a bi-specific full-length human antibody targeting Fzd5/8 and Lrp6 receptors in development for the treatment of IBD. A third poster presentation discussed expression profiling of Wnt pathway genes in colon biopsies from patients with ulcerative colitis (UC). Copies of posters will be available in the Investors & Media section of Surrozen’s website.
“In both chronic and acute models presented at this congress, SZN-1326 demonstrated beneficial activity compared to other therapeutics currently used for the treatment of IBD that we believe could be meaningful for patients living with IBD,” said Craig Parker, President and Chief Executive Officer of Surrozen. “Combined with presented data about Wnt expression and our other studies of SZN-1326, we continue to be excited for this program and look forward to moving it into clinical investigation in 2022.”
In a poster presentation titled, “SZN-1326, a Wnt agonist, improved epithelial healing and ameliorated colitis in a chronic DSS model, in stark contrast to anti-TNFa and anti-IL-12/23p40 antibodies,” findings from a chronic mouse IBD model showed SZN-1326 at various dosing regimens stimulated intestinal epithelial regeneration, induced mucosal healing and restored the epithelial barrier resulting in reduced inflammation, reduced serum cytokine levels, improved body weight and reduced disease activity. In contrast, treatment with anti-TNFa or anti-IL-12/23p40 antibodies led to reduction only in certain serum inflammatory cytokines but had no effect on disease activity or colon histology in this model.
In a poster presentation titled, “SZN-1326, a Wnt signal activator, is more efficacious than cyclosporine A in an acute DSS model,” findings from an acute mouse IBD model showed SZN-1326 at various dosing regimens stimulated intestinal epithelial regeneration, induced mucosal healing and restored the epithelial barrier resulting in reduced inflammation, reduced serum cytokine and lipocalin-2 levels improved body weight and reduced disease activity. In comparison, Cyclosporine A showed only a mild effect on reducing disease activity and lipocalin-2.
In a poster presentation titled, “Expression profiling of Wnt pathway genes in colon biopsies of patients with ulcerative colitis,” shows reduced expression of Wnt receptors, RSPOs and Wnt target genes indicated insufficient Wnt signal induction in the damaged colon epithelium of UC patients. The findings suggest that repair of the damaged epithelium by Wnt agonist treatment may constitute a new mechanism of action and benefit patients with UC.
About Wnt Signaling
Wnt signaling plays key roles in the control of development, homeostasis, and regeneration of many essential organs and tissues, including liver, intestine, lung, kidney, retina, central nervous system, cochlea, bone, and others. Modulation of Wnt signaling pathways has potential for treatment of degenerative diseases and tissue injuries. Surrozen’s platform and proprietary technologies have the potential to overcome the limitations in pursuing the Wnt pathway as a therapeutic strategy.
About Surrozen
Surrozen is a biotechnology company discovering and developing drug candidates to selectively modulate the Wnt pathway. Surrozen is developing tissue-specific antibodies designed to engage the body’s existing biological repair mechanisms with potential application across multiple disease areas, including inflammatory bowel disease, hepatitis, eye diseases, hearing loss, lung and airway diseases, and certain neurological disorders. For more information, please visit surrozen.com.
SOURCE: Surrozen
Post Views: 135
Company to advance SZN-1326 toward first-in-human clinical studies in 2022
SOUTH SAN FRANCISCO, CA, USA I July 09, 2021 I Surrozen Inc., a biotechnology company discovering and developing drug candidates to selectively modulate the Wnt pathway, announced today that new data from its inflammatory bowel disease (IBD) program, including preclinical studies of SZN-1326 showing superior activity compared to therapeutics currently used in treatment, were presented during the 16th Congress of the European Crohn’s and Colitis Organisation.
Two poster presentations discussed data from studies of SZN-1326, a bi-specific full-length human antibody targeting Fzd5/8 and Lrp6 receptors in development for the treatment of IBD. A third poster presentation discussed expression profiling of Wnt pathway genes in colon biopsies from patients with ulcerative colitis (UC). Copies of posters will be available in the Investors & Media section of Surrozen’s website.
“In both chronic and acute models presented at this congress, SZN-1326 demonstrated beneficial activity compared to other therapeutics currently used for the treatment of IBD that we believe could be meaningful for patients living with IBD,” said Craig Parker, President and Chief Executive Officer of Surrozen. “Combined with presented data about Wnt expression and our other studies of SZN-1326, we continue to be excited for this program and look forward to moving it into clinical investigation in 2022.”
In a poster presentation titled, “SZN-1326, a Wnt agonist, improved epithelial healing and ameliorated colitis in a chronic DSS model, in stark contrast to anti-TNFa and anti-IL-12/23p40 antibodies,” findings from a chronic mouse IBD model showed SZN-1326 at various dosing regimens stimulated intestinal epithelial regeneration, induced mucosal healing and restored the epithelial barrier resulting in reduced inflammation, reduced serum cytokine levels, improved body weight and reduced disease activity. In contrast, treatment with anti-TNFa or anti-IL-12/23p40 antibodies led to reduction only in certain serum inflammatory cytokines but had no effect on disease activity or colon histology in this model.
In a poster presentation titled, “SZN-1326, a Wnt signal activator, is more efficacious than cyclosporine A in an acute DSS model,” findings from an acute mouse IBD model showed SZN-1326 at various dosing regimens stimulated intestinal epithelial regeneration, induced mucosal healing and restored the epithelial barrier resulting in reduced inflammation, reduced serum cytokine and lipocalin-2 levels improved body weight and reduced disease activity. In comparison, Cyclosporine A showed only a mild effect on reducing disease activity and lipocalin-2.
In a poster presentation titled, “Expression profiling of Wnt pathway genes in colon biopsies of patients with ulcerative colitis,” shows reduced expression of Wnt receptors, RSPOs and Wnt target genes indicated insufficient Wnt signal induction in the damaged colon epithelium of UC patients. The findings suggest that repair of the damaged epithelium by Wnt agonist treatment may constitute a new mechanism of action and benefit patients with UC.
About Wnt Signaling
Wnt signaling plays key roles in the control of development, homeostasis, and regeneration of many essential organs and tissues, including liver, intestine, lung, kidney, retina, central nervous system, cochlea, bone, and others. Modulation of Wnt signaling pathways has potential for treatment of degenerative diseases and tissue injuries. Surrozen’s platform and proprietary technologies have the potential to overcome the limitations in pursuing the Wnt pathway as a therapeutic strategy.
About Surrozen
Surrozen is a biotechnology company discovering and developing drug candidates to selectively modulate the Wnt pathway. Surrozen is developing tissue-specific antibodies designed to engage the body’s existing biological repair mechanisms with potential application across multiple disease areas, including inflammatory bowel disease, hepatitis, eye diseases, hearing loss, lung and airway diseases, and certain neurological disorders. For more information, please visit surrozen.com.
SOURCE: Surrozen
Post Views: 135
