Tedizolid Met All Primary and Secondary Efficacy Outcomes Designated by the FDA and EMA
SAN DIEGO, CA, USA I March 25, 2013 I Trius Therapeutics, Inc. (TSRX) today announced top-line results from its ESTABLISH 2 Phase 3 clinical trial of tedizolid phosphate (TR-701) for the treatment of acute bacterial skin and skin structure infections (ABSSSI), including methicillin resistant Staphylococcus aureus (MRSA). As in the ESTABLISH 1 study, which tested the oral dosage form of tedizolid, the ESTABLISH 2 intravenous (IV) to oral transition study captured the endpoints for ABSSSI established by both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).
Trius conducted the trial at 95 sites in North and South America, Europe, Australia, New Zealand and South Africa. The randomized, double-blind, placebo-controlled study enrolled 666 patients with ABSSSI. Patients received either 200 mg of tedizolid once a day for six days of treatment plus four days of placebo or 600 mg of linezolid (Zyvox(R)) twice a day for 10 days of treatment. Patients initially received the IV dosage form of either tedizolid or linezolid with the option to switch to the respective oral dosage forms at the discretion of the clinical investigator on or after the second day of treatment.
Tedizolid met its primary endpoint of non-inferiority (10% NI margin) to linezolid as measured by a 20 percent or greater reduction in lesion area at 48 to 72 hours after the first infusion of study drug. Tedizolid also met all secondary efficacy endpoints measured at both the end of therapy and post treatment evaluations.
Clinical Response
| ITT Analysis Set | Tedizolid 6 days treatment, % (n = 332) |
Linezolid 10 days treatment, % (n = 334) |
Treatment Difference (95% CI), % |
|
| Primary Endpoint | >=20% decrease from baseline in lesion area at 48-72 hours |
85.2 | 82.6 | 2.6 (-3.0 to 8.2) |
| Key Secondary Endpoints | Sustained clinical response at end of therapy |
87.0 | 88.0 | -1.0 (-6.1 to 4.1) |
| Investigators assessment of clinical response at 7-14 days after end of therapy |
88.0 | 87.7 | 0.3 (-4.8 to 5.3) | |
| Sensitivity analysis (2010 FDA guidance) |
Cessation of spread and absence of fever at 48-72 hours |
85.8 | 81.4 | 4.4 (-1.2 to 10.1) |
As in the ESTABLISH 1 study, both tedizolid and linezolid were generally well tolerated in ESTABLISH 2 with drug-related treatment emergent adverse events (TEAE) reported in 20.5% of tedizolid patients versus 24.8% of linezolid treated patients. Gastrointestinal adverse events were the most commonly reported of all TEAEs (16.0% in tedizolid vs. 20.5% in linezolid).
"The consistently strong results of the two Phase 3 studies support the promise of tedizolid as a safe and effective new antibiotic, especially in an era of increasing multi-drug resistant Staphylococcus aureus," said Andrew F. Shorr, M.D. MPH, Associate Professor of Medicine, Washington Hospital Center, Washington, D.C. "The potential to treat severe MRSA infections with a novel once-daily agent and a shorter course of therapy offers substantial benefits to patients and, potentially, payers and the healthcare system."
"These results confirm Trius’ ability to successfully execute a comprehensive clinical program intended to support global approval," said Jeffrey Stein, Ph.D., President and Chief Executive Officer of Trius. "We are committed to responding to the needs of patients and physicians worldwide for new and effective antibiotics. Looking ahead, we intend to file our NDA for tedizolid as well as initiate a Phase 3 study of tedizolid in patients with severe pneumonia during the second half of this year."
Data from the ESTABLISH 1 study, which tested the oral dosing of tedizolid, were published in The Journal of the American Medical Association (JAMA) in February 2013. "The collective results of ESTABLISH 1, ESTABLISH 2 and additional clinical studies support the differentiated profile of tedizolid and pave the way for new drug application (NDA) and marketing authorization application (MAA) submissions in the U.S. and European Union, respectively," added Dr. Philippe Prokocimer, Chief Medical Officer of Trius.
Scheduled Conference Call
The Company will host a conference call to discuss the results today, March 25, 2013, at 9:00 a.m. Eastern Time (6:00 a.m. Pacific Time). The conference call may be accessed by calling (877) 303-9219 for domestic callers and (760) 666-3559 for international callers. Please specify to the operator that you would like to join the "Trius Therapeutics Conference Call." The conference call will also be webcast live under the Investors section of the Trius website at http://investor.triusrx.com, where it will be archived for 30 days following the call.
About Trius Therapeutics
Trius Therapeutics, Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for serious infections. The Company’s lead investigational drug, tedizolid phosphate, is a novel antibiotic in Phase 3 clinical development for the treatment of serious gram-positive infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). Trius has partnered with Bayer HealthCare for the development and commercialization of tedizolid phosphate outside of the U.S., Canada and the European Union. In addition to the Company’s tedizolid phosphate clinical program, Trius has initiated Investigational New Drug (IND) enabling studies for its Gyrase-B development candidate with potent activity against Gram-negative bacterial pathogens including multi-drug resistant strains of E. coli, Klebsiella, Acinetobacter and Pseudomonas. For more information, visit www.triusrx.com.
SOURCE: Trius Therapeutics
