May Also Use Discovery for Treatment of Other Autoimmune Diseases
SCOTTSDALE, AZ, USA | January 5, 2010 | InNexus Biotechnology Inc. (TSX.V:IXS, www.ixsbio.com), a drug development company commercializing the next generation of antibodies based on its groundbreaking Dynamic Cross Linking (DXL™) technology, today announced the development of a new psoriasis product based on its proprietary dermal permeating Transmab™ technology.
Scientists at InNexus have designed and produced by recombinant technology, a novel antibody product directed at treatment of psoriasis, an autoimmune skin disease. The product, designated IXSCD11a, is being formulated for topical use either as a lotion or in patches to be applied to affected areas. IXSCD11a is an antibody fragment based on InNexus’ Transmab technology that penetrates cell membranes and dermal barriers. IXSCD11a has shown significant increase in cell penetration compared to other products targeting psoriasis.
Dr. Thomas Kindt, InNexus’ CSO said, “The target bound by the antibody fragment is a cell surface molecule involved in inflammation, which is a factor in the development of psoriasis as well as a number of other autoimmune conditions. It binds the CD11a receptor that is key to the immune cell-cell interactions that lead to inflammatory processes causative of the painful and disfiguring psoriatic lesions. A full-length antibody product previously marketed by another company with specificity for this receptor was used successfully for treatment of the most serious forms of psoriasis, but was withdrawn due to incidences of fatal brain infection caused by systemic immunosuppression. IXSCD11a was designed to circumvent this side effect because low molecular weight antibody fragments do not persist in circulation long enough to mediate systemic immune suppression. In contrast to full-length antibodies that persist in the blood stream with half-lives of 18-24 days, antibody fragments like IXSCD11a are eliminated within 3 hours. Immune-suppressive activity of IXSCD11a is likely to be confined to the region of application and eliminated rapidly.”
Jeff Morhet, CEO of InNexus said, “2009 might have been a year for survival but 2010 is a year for biotech companies to differentiate and show their value. It is our aim to develop safe and effective treatments for disease conditions that cause physical and mental suffering to millions of people. Our IXSCD11a product combines the proven efficacy of previous products with a desired and reassuring safety profile. This is exciting science.”
According to the National Psoriasis Foundation (http://www.psoriasis.org), psoriasis affects 125 million people worldwide (2-3% of total population) and is present in all racial groups in varying rates. Psoriasis is the most prevalent autoimmune disease in the U.S. affecting 7.5 million people.
About InNexus Biotechnology
InNexus Biotechnology Inc. is a public biotechnology company commercializing the next generation of monoclonal antibodies based on its DXL™ and Transmab™ technology to improve the potency of existing antibodies and to develop novel antibodies based on the unique and patented mehods and technologies of InNexus. Headquartered in British Columbia with principal management based in Scottsdale, Arizona on the campus of Mayo Clinic, InNexus has its own in-house developmental (GLP) and manufacturing (GMP) facilities, enabling InNexus (and its strategic partners) to advance novel drug therapeutics and diagnostics. InNexus Biotechnology Inc. is listed on the TSX Venture Exchange (TSX.V:IXS). Please visit www.ixsbio.com.
SOURCE: InNexus Biotechnology Inc.
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May Also Use Discovery for Treatment of Other Autoimmune Diseases
SCOTTSDALE, AZ, USA | January 5, 2010 | InNexus Biotechnology Inc. (TSX.V:IXS, www.ixsbio.com), a drug development company commercializing the next generation of antibodies based on its groundbreaking Dynamic Cross Linking (DXL™) technology, today announced the development of a new psoriasis product based on its proprietary dermal permeating Transmab™ technology.
Scientists at InNexus have designed and produced by recombinant technology, a novel antibody product directed at treatment of psoriasis, an autoimmune skin disease. The product, designated IXSCD11a, is being formulated for topical use either as a lotion or in patches to be applied to affected areas. IXSCD11a is an antibody fragment based on InNexus’ Transmab technology that penetrates cell membranes and dermal barriers. IXSCD11a has shown significant increase in cell penetration compared to other products targeting psoriasis.
Dr. Thomas Kindt, InNexus’ CSO said, “The target bound by the antibody fragment is a cell surface molecule involved in inflammation, which is a factor in the development of psoriasis as well as a number of other autoimmune conditions. It binds the CD11a receptor that is key to the immune cell-cell interactions that lead to inflammatory processes causative of the painful and disfiguring psoriatic lesions. A full-length antibody product previously marketed by another company with specificity for this receptor was used successfully for treatment of the most serious forms of psoriasis, but was withdrawn due to incidences of fatal brain infection caused by systemic immunosuppression. IXSCD11a was designed to circumvent this side effect because low molecular weight antibody fragments do not persist in circulation long enough to mediate systemic immune suppression. In contrast to full-length antibodies that persist in the blood stream with half-lives of 18-24 days, antibody fragments like IXSCD11a are eliminated within 3 hours. Immune-suppressive activity of IXSCD11a is likely to be confined to the region of application and eliminated rapidly.”
Jeff Morhet, CEO of InNexus said, “2009 might have been a year for survival but 2010 is a year for biotech companies to differentiate and show their value. It is our aim to develop safe and effective treatments for disease conditions that cause physical and mental suffering to millions of people. Our IXSCD11a product combines the proven efficacy of previous products with a desired and reassuring safety profile. This is exciting science.”
According to the National Psoriasis Foundation (http://www.psoriasis.org), psoriasis affects 125 million people worldwide (2-3% of total population) and is present in all racial groups in varying rates. Psoriasis is the most prevalent autoimmune disease in the U.S. affecting 7.5 million people.
About InNexus Biotechnology
InNexus Biotechnology Inc. is a public biotechnology company commercializing the next generation of monoclonal antibodies based on its DXL™ and Transmab™ technology to improve the potency of existing antibodies and to develop novel antibodies based on the unique and patented mehods and technologies of InNexus. Headquartered in British Columbia with principal management based in Scottsdale, Arizona on the campus of Mayo Clinic, InNexus has its own in-house developmental (GLP) and manufacturing (GMP) facilities, enabling InNexus (and its strategic partners) to advance novel drug therapeutics and diagnostics. InNexus Biotechnology Inc. is listed on the TSX Venture Exchange (TSX.V:IXS). Please visit www.ixsbio.com.
SOURCE: InNexus Biotechnology Inc.
Post Views: 555
