SAN DIEGO, CA, USA I May 9, 2024 I Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today announced the initiation of its Phase 1 first-in-human clinical study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of investigational compound NBI-1076986 in healthy adult participants. NBI-1076986 is an investigational, oral, M4 subtype-selective muscarinic acetylcholine receptor antagonist for the potential treatment of movement disorders that was discovered and developed by Neurocrine Biosciences.

“This compound is an important part of our muscarinic portfolio, which enters the clinic as a potential treatment for movement disorders,” said Eiry W. Roberts, M.D., Chief Medical Officer at Neurocrine Biosciences. “Selectively targeting M4 receptors could benefit a broad range of motor coordination disorders, including Parkinson’s disease tremor and dystonia.”

About Muscarinic Pipeline and NBI-1076986
Muscarinic receptors are fundamental to activating signaling pathways in the brain. There are five muscarinic acetylcholine receptors involved in neurotransmission (M1–M5), with M4 receptors associated with motor coordination and certain central nervous system pathologies. M1 receptors play a role in higher cognitive processes such as learning and memory and are thought to be associated with the memory/cognitive side effects associated with non-selective antimuscarinic agents.

Identified and developed by Neurocrine Biosciences, NBI-1076986 is an investigational, oral, M4 subtype-selective muscarinic acetylcholine receptor antagonist for the potential treatment of certain movement disorders, including Parkinson’s disease tremor and dystonia. It is hypothesized that an M4 subtype-selective antagonist may impact regulation of motor symptoms and movements while minimizing off-target effects.

Neurocrine Biosciences has a broad portfolio of programs that selectively target muscarinic receptors. In addition to NBI-1076986, the portfolio includes several small molecule M1, M1/M4 and M4 agonists that Neurocrine Biosciences acquired the rights to develop and commercialize from Nxera Pharma (formerly Sosei Heptares). 

About Neurocrine Biosciences 
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit, and follow the company on LinkedIn, X (formerly Twitter, and Facebook.
(*in collaboration with AbbVie)

SOURCE: Neurocrine Biosciences