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Hypoxia-Inducible Factor (HIF)
The present Competitive Intelligence Report about Hypoxia-Inducible Factor (HIF) provides a competitor evaluation in the field of investigational small molecules and RNA inhibiting HIF-1alpha or HIF-2 for treatment of cancer or acting as HIF agonists to induce angiogenesis as of April 2009.
Hypoxia-inducible factor 1 (HIF-1) is a key regulator of angiogenic and glucose metabolism processes utilised by tumour cells for survival and growth under hypoxic conditions. While HIF-1α protein is found in a wide variety of human primary tumors, it is only produced at very low levels in normal tissue. Because of the important role that HIF-1α plays in regulating the response of growing tumors to hypoxia, the protein is expected to have substantial value as a target for therapeutic intervention. The protein is a key regulator of a large number of genes important in cancer biology, including genes that regulate angiogenesis, cell metabolism, cell proliferation, cell death (apoptosis) and cell invasion. The first molecules inhibiting HIF-1alpha have entered clinical development and others are to follow shortly including small molecules and RNA interfering agents.
The report includes a compilation of current active projects in research and development of HIF targeting small molecules, RNA or DNA. In addition, the report lists company-specific R&D pipelines of HIF targeting molecules. Competitor projects are listed in a tabular format providing information on:
- Drug Codes,
- Target / Mechanism of Action,
- Class of Compound,
- Product Category,
- R&D Stage and
- additional comments with a hyperlink leading to the source of information.
- HIF-1alpha Inhibitors
- HIF-2 Inhibitors
- HIF Agonists
- Corporate HIF R&D Pipelines
- About La Merie
About Competitor Analysis Series
The Competitor Analysis Series delivers NO-FRILLS , but concise information about the pipeline of R&D projects for targets, diseases, technologies and companies at low prices. The information is provided in a tabular format and fully referenced. Competitor analysis reports can be purchased as individual products or obtained by subscribing to R&D Pipeline News. R&D Pipeline News is published weekly 50-times a year and each issue contains at least two competitor evaluations. Individual products from the Competitor Analysis Series and R&D Pipeline News are independently elaborated by analysts of La Merie Business Intelligence and distributed by PipelineReview.com.