Botulinum Neurotoxins: A comparative industry analysis of products, pipelines, technologies and stakeholders
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Botulinum Neurotoxins: A comparative industry analysis of products, pipelines, technologies and stakeholders
This business report from July 2014 is based on the identification, description and assessment of all relevant stakeholders in the field of botulinum neurotoxins. The report analyzes the existing product portfolios in regulated and less regulated markets, commercial information, and measures to maintain sales and market shares by upside indications and life cycle management measures. The report addresses the new wave of botulinum neurotoxin product candidates in development, such as biosimilars and biosuperior botulinum neurotoxins.
Special emphasis is put in the report on improvements by pharmaceutical technologies, such as liquid protein formulations and transdermal drug delivery technologies. The significance of recombinant DNA technology is discussed regarding botulinum neurotoxin engineering, modification and manufacturing. Chances and challenges for the stakeholders in the botulinum neurotoxin market are evaluated.
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The market for botulinum neurotoxin products has significantly grown over the last years, due to new medical indications developed and due to more cosmetic procedures performed with botulinum neurotoxins in ageing societies in which physical appearance is highly valued. Although the botulinum neurotoxin market commercially is dominated by only one company, existing competitors, new players and technologies are setting the ground for biosuperiors as well as for biosimilars. As biosimilar botulinum toxins will put the price of first generation products under pressure, only innovation can justify higher prices.
Benefits from the report:
- Identify established and emerging players in the field;
- Find out which enabling technologies are attractive for the next generation;
- Understanding the driving forces for the future of the botulinum neurotoxin market;
- Learn the key success factors in marketing new botulinum neurotoxin products;
- Recognize the challenges acting on established stakeholders;
- Learn which technologies and product candidates are attractive for partnering;
Botulinum Neurotoxins: A comparative industry analysis of products, pipelines, technologies and stakeholders
Table of Contents
1. Executive Summary
2. Overview
2.1 Historical Background
2.2 Structure and Function of Botulinum Neurotoxins (BoNT)
3. Botulinum Neurotoxin Products Available in Regulated Markets
3.1 Approved indications of BoNTs in regulated markets
3.2 Key product features of BoNT products in regulated markets
3.3 Pricing of botulinum toxin products in regulated markets
3.4 Botulinum toxin product sales and market shares
3.5 Commercial BoNT product success factors
3.6 Pipeline in a product
3.7 Product life cycle management of BoNT in EU/US
3.8 Discontinued development of BoNT in EU/US
4. BoNTs in Less Regulated Markets
5. Biosimilar Botulinum Neurotoxin
6. Biosuperior, Next Generation Botulinum Neurotoxins
6.1 Ready-to-use injectable BoNT in liquid formulation
6.2 Transdermal delivery of BoNT in topical formulation
6.3 Engineered and modified botulinum toxins
7. Botulinum Neurotoxin Market Stakeholders and Enabling Technologies
7.1 The established Western market players
7.2 Challenges for established BoNT market players
7.3 Enabling technologies for next generation BoNT
8. Botulinum Neurotoxin Company Profiles
Allergan
Alphaeon
Anterios
CROMA Pharma
Daewoong Pharmaceutical Co
Eisai
Escape Therapeutics
Galderma
Hugel
Ipsen
Johnson & Johnson (Mentor)
Lanzhou Institute of Biological Producs (LIBP)
Lipella Pharmaceuticals
Malvern Cosmeceutics
Medy-Tox
Merz Pharmaceuticals
OBI Pharma
Revance Therapeutics
Transdermal Corp
US WorldMeds
9. References
10. Competitor Analysis Tables
OnabotulinumtoxinA Pipeline
AbobotulinumtoxinA Pipeline
IncobotulinumtoxinA Pipeline
RimabotulinumtoxinB Pipeline
Novel and Biosimilar Botulinum Neurotoxin type A (BoNT/A) in Regulated Markets
Botulinum Neurotoxin type A (BoNT/A) in Less Regulated Markets
Liquid Formulation of Botulinum Neurotoxin type A (BoNT/A)
Topical Formulation of Botulinum Neurotoxin type A (BoNT/A)
Modified/Engineered Botulinum Neurotoxin
Corporate Botulinum Toxin Product Portfolios and R&D Pipelines:
Allergan
Alphaeon
Anterios
CROMA Pharma
Daewoong Pharmaceutical Co
Eisai
Escape Therapeutics
Galderma
Hugel
Ipsen
Johnson & Johnson (Mentor)
Lanzhou Institute of Biological Producs (LIBP)
Lipella Pharmaceuticals
Malvern Cosmeceutics
Medy-Tox
Merz Pharmaceuticals
OBI Pharma
Revance Therapeutics
Transdermal Corp
US WorldMeds
Botulinum Neurotoxins: A comparative industry analysis of products, pipelines, technologies and stakeholders
List of Tables
Table 1 Comparison of Approved Indications of Botulinum Toxins in EU/US
Table 2 Comparison of Pharmaceutical Product Features of BoNTs in EU/US
Table 3 Pricing of Botulinum Toxin Products in EU/US
Table 4 Worldwide Sales of Botox and Dysport
Table 5 Scientific Evidence from Peer-reviewed Literature about Marketed BoNTs in EU/US
Table 6 Pipeline in a Product: Comparison of Follow-up Indications of BoNTs in EU/ US
Table 7 Comparison of Product Features of non-US/EU-GMP Compliant BoNTs
Table 8 Comparison of Product Features of Potential Biosimilar BoNTs for EU/US Markets
Table 9 Comparison of Product Features of Liquid BoNTs for EU/US Markets
Table 10 Comparison of Product Features of Topical Botulinum Toxins
Table 11 Overview of Engineered and Modified Botulinum Toxin R&D Projects
Table 12 Present and Future Key Success Factors for Established BoNT Players in EU/US
Table 13 Global Botox/Vistabel Sales and US Approval of New Indications
Table 14 Key Product Features of Botox
Table 15 Medical and cosmetic indications of Botox under development
Table 16 Key Product Features of Senrebotase
Table 17 Postherpetic Neuralgia Study Results of Senrebotase
Table 18 Overview on clinical studies conducted with Anterios‘ topical botulinum toxin typ A cream
Table 19 Key Product Features of ANT-1207
Table 20 Key Product Features of AI-09
Table 21 Key Product Features of Nabota
Table 22 Overview on Commercialization of Nabota
Table 23 NeuroBloc Pruduct Characteristics
Table 24 Azzalure Pruduct Characteristics
Table 25 Key Product Features of Botulax
Table 26 Overview on Commercialization of Botulax
Table 27 Dysport Pruduct Characteristics
Table 28 Dysport sales
Table 29 Key Product Features of PurTox
Table 30 Key Product Features of BTXA
Table 31 Key Product Features of Meditoxin
Table 32 Formulation Patent Applications by Medytox
Table 33 Xeomin Pruduct Characteristics
Table 34 IncobotulinumtoxinA Sales
Table 35 Financing history of Revance Therapeutics
Table 36 Key Product Features of RT001
Table 37 Key Product Features of RT002
Table 38 Key Product Features of CosmeTox / Topical BoNTA
Table 39 Key Product Features of A2NTX
Table 40 Myobloc Pruduct Characteristics
Botulinum Neurotoxins: A comparative industry analysis of products, pipelines, technologies and stakeholders
Companies mentioned in the report
Allergan
Alphaeon
Anterios
Bago
Bon-Song
Chong Kun Dang
CROMA Pharma
Daewoong Pharmaceutical Co
Eisai
EpiVax
Escape Therapeutics
Galderma
GlaxoSmithKline
Hugel
Ipsen
Johnson & Johnson
Lanzhou Institute of Biological Producs (LIBP)
Lipella Pharmaceuticals
List Biological Laboratories
Malvern Cosmeceutics
Medicis
Medy-Tox
Mentor Corp.
Merz Pharmaceuticals
Metabiologics
Nestle
OBI Pharma
Oxbridge Pharma
PharmaVital
Revance Therapeutics
Syntaxin
TKJ
Transdermal Corp
University of Tokushima
US WorldMeds
Valeant Pharmaceuticals