Vir Biotechnology Announces Amended Collaboration Agreement with GSK

Vir to continue advancing next-generation COVID-19 solutions independently or with other partners –

– The Companies will continue working together to ensure ongoing access to sotrovimab for patients around the world, where authorized, and to advance new therapies for influenza and other respiratory diseases –

SAN FRANCISCO, CA, USA I February 13, 2023 I Vir Biotechnology, Inc. (Nasdaq: VIR) today announced that the research collaboration agreement established with GSK in 2020 has been amended to reflect that Vir will continue its ongoing efforts to discover, develop and advance next-generation solutions for COVID-19 and other potential coronavirus outbreaks, independently or with other partners. Together, the Companies will continue working to ensure ongoing access to sotrovimab for patients around the world, where authorized, and to develop new therapies for influenza and other respiratory diseases.

George Scangos, Ph.D., Chief Executive Officer of Vir Biotechnology, said: “Our rapid response to the COVID-19 pandemic and ability to provide an important new treatment option to millions of patients around the world was made possible through our collaboration with GSK. Together, we remain committed to sotrovimab and to continuing to build on our successful partnership through the development of new solutions for respiratory diseases. Our collaborative efforts have also yielded a compelling portfolio of next-generation coronavirus solutions that, given Vir’s infectious disease expertise, we plan to pursue independently. We look forward to advancing both efforts simultaneously and continuing to support urgent patient needs.”

About the Collaboration
In April 2020, GSK and Vir entered into a collaboration to research and develop solutions for coronaviruses, including SARS-CoV-2, the virus that causes COVID-19. The collaboration used Vir’s proprietary monoclonal antibody platform technology to accelerate existing and identify new anti-viral antibodies that could be developed as therapeutic or preventive options to help address the COVID-19 pandemic and future outbreaks. In 2021, the Companies expanded their collaboration to include the research and development of new therapies for influenza and other respiratory viruses.

Under the terms of the new amended agreement, Vir retains the sole rights to continue advancing next-generation solutions arising from the collaborative coronavirus vaccine and antibody programs, subject to tiered low- to mid-single digit royalties to GSK. The Companies continue to collaborate on sotrovimab and VIR-7832, as well as a portfolio of other respiratory disease programs.

About Sotrovimab
Sotrovimab is an investigational SARS-CoV-2 neutralizing monoclonal antibody. The antibody binds to an epitope on SARS-CoV-2 shared with SARS-CoV-1 (the virus that causes SARS), indicating that the epitope is conserved. Sotrovimab, which incorporates Xencor, Inc.’s Xtend™ technology, has also been designed to achieve high concentration in the lungs to ensure optimal penetration into airway tissues affected by SARS-CoV-2 and to have an extended half-life. Sotrovimab is currently not authorized in the US.

Vir’s Commitment to COVID-19
Vir was founded with the mission of addressing the world’s most serious infectious diseases. In 2020, Vir responded rapidly to the COVID-19 pandemic by leveraging our unique scientific insights and industry-leading antibody platform to explore multiple monoclonal antibodies as potential therapeutic or preventive options for COVID-19. Sotrovimab is the first SARS-CoV-2-targeting antibody Vir advanced into the clinic. It was carefully selected for its demonstrated promise in preclinical research and potential ability to both block the virus from entering healthy cells and clear infected cells. Vir is continuing to pursue novel therapeutic and prophylactic solutions to combat SARS-CoV-2 and future coronavirus pandemics, both independently and in collaboration with its partners.

About Vir Biotechnology
Vir Biotechnology is a commercial-stage immunology company focused on combining immunologic insights with cutting-edge technologies to treat and prevent serious infectious diseases. Vir has assembled four technology platforms that are designed to stimulate and enhance the immune system by exploiting critical observations of natural immune processes. Its current development pipeline consists of product candidates targeting COVID-19, hepatitis B and hepatitis D viruses, influenza A and human immunodeficiency virus. Vir routinely posts information that may be important to investors on its website.

SOURCE: Vir Biotechnology

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