Centessa Pharmaceuticals Announces Non-Human Primate Pharmacokinetic and Safety Data for LB101 (PD-L1xCD47) Demonstrating Potential for Enhanced Therapeutic Index

Data support continued advancement of LB101 toward IND submission late this year

BOSTON, MA, USA and LONDON, UK I September 12, 2022 I Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company with a Research & Development (“R&D”) innovation engine that aims to discover, develop, and ultimately deliver impactful medicines to patients, today announced non-clinical pharmacokinetic (PK) and safety data in non-human primates (NHPs) for LB101 (PD-L1xCD47), its first LockBody® candidate for solid tumors. Findings from these data reinforce the potential of its LockBody platform to minimize the systemic effects of potent immune effectors and significantly improve the therapeutic index. Centessa management will discuss the data during the Morgan Stanley 20th Annual Global Healthcare Conference taking place today at 8:45 am ET.

“These data, together with the non-clinical data presented at ASCO earlier this year, continue to validate our novel LockBody pharmacology, which leverages the natural cleaving of the human IgG-derived hinge to deliver powerful effectors like anti-CD47 into the tumor environment,” said Saurabh Saha, MD, PhD, Chief Executive Officer of Centessa. “Whereas current therapies targeting CD47 are encumbered with severe toxicities due to peripheral activity on circulating red blood cells, LB101 has the potential to optimally deliver anti-PD-L1 activity plus targeted anti-CD47 activity to the tumor micro-environment. These new non-clinical data demonstrate systemic delivery of high doses of LB101 without hematological toxicity in non-human primates, resulting in the potential to achieve an enhanced therapeutic index, increased anti-tumor activity, and enable meaningful treatment for patients with solid tumors. We look forward to advancing LB101 into the clinic and plan to submit an IND late this year.”

In the study, male and female cynomolgus monkeys were administered LB101 intravenously, every 7 days over 28 days (q7 days x 4) at doses of 5mg/kg, 20mg/kg, and 50mg/kg. The pharmacokinetics of LB101 were assessed and exhibited a typical IgG1-like PK profile. There were no adverse changes in hematologic parameters (including no anemia and no thrombocytopenia), no changes in body weights and no adverse toxicology findings.

Event: Morgan Stanley 20th Annual Global Healthcare Conference
Date: Monday, September 12, 2022
Location: New York City, NY
Fireside Chat Time: 8:45 AM ET

Access to the live and archived recording of the webcast of the fireside chat, as well as a copy of the Company’s slides that will be used at the conference, will be available under the “Events and Publications” tab on the investor relations section of the Centessa Pharmaceuticals website at https://investors.centessa.com/events-presentations.

About Centessa Pharmaceuticals
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company with an R&D innovation engine that aims to discover, develop, and ultimately deliver impactful medicines to patients. Our programs span discovery-stage to late-stage development and cover a range of high-value indications in rare diseases and immuno-oncology. We are led by a management team with extensive R&D experience, providing direct guidance to our program teams to rapidly advance our candidates from research through all stages of development. For more information, visit www.centessa.com, which does not form part of this release.

SOURCE: Centessa Pharmaceuticals

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