NextCure Initiates Phase 1/2 Clinical Study of NC410, a Novel Immunomedicine, for Solid Tumors

BELTSVILLE, MD, USA I July 07, 2020 I NextCure, Inc. (Nasdaq: NXTC), a clinical-stage biopharmaceutical company committed to discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases, today announced the initiation of a Phase 1/2 clinical trial for NC410, a novel immunomedicine developed to block immune suppression mediated by an immune modulator called LAIR-1.

The Phase 1 dose-escalation portion of this open-label trial is designed to evaluate the safety and tolerability of NC410 in patients with advanced or metastatic solid tumors and determine its pharmacologically active and/or maximum tolerated dose. After a recommended dose for the Phase 2 portion of the trial is determined, the efficacy of NC410 will be evaluated in select tumor types.

“We are pleased to initiate this first clinical trial of NC410, our second product candidate to reach the clinic, after a brief delay announced in April as a result of the COVID-19 pandemic. This is a significant step in building our pipeline of next-generation immunomedicines to treat cancer,” said Michael Richman, NextCure’s president and chief executive officer. “We are the first company to target the LAIR protein family in the clinic. NC410 is a biomimic of LAIR-2, a naturally occurring immune regulatory protein. We look forward to continuing development of both NC318 and NC410, as well as advancing our preclinical pipeline.”

Leukocyte-Associated Immunoglobulin-like Receptor 1, or LAIR-1, is a co-inhibitory receptor expressed on T cells, monocytes, macrophages and dendritic cells. LAIR-2 is a naturally occurring soluble version of LAIR-1, which binds to and blocks the inhibitory activity of LAIR-1 and thus acts as a decoy protein. NC410 is a recombinant LAIR-2 fusion protein designed to mimic the natural decoy effects of LAIR-2. Preclinical research showed that LAIR-1 inhibits T cell function and dendritic cell activity, allowing tumor cells to grow. In preclinical studies, NC410 blocked LAIR-1 mediated inhibition of T cells and dendritic cells, thus promoting their activity.

The company anticipates initial data from the Phase 1 portion of the trial by the second half of 2021.

About NextCure, Inc.
NextCure is a clinical-stage biopharmaceutical company committed to discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases. Through our proprietary FIND-IO™ platform, we study various immune cells to discover and understand targets and structural components of immune cells and their functional impact in order to develop immunomedicines. Our initial focus is to bring hope and new treatments to patients who do not respond to current cancer therapies, patients whose cancer progresses despite treatment and patients with cancer types not adequately addressed by available therapies. www.nextcure.com

SOURCE: NextCure

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