Morphic Therapeutic Presents Positive Preclinical Data Supporting Development of MORF-057 in Inflammatory Bowel Disease at Digestive Disease Week 2020
- Category: Small Molecules
- Published on Monday, 29 June 2020 18:24
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Receptor occupancy, potency and selectivity data further build MORF-057 preclinical profile as an oral small molecule treatment candidate for IBD
IND filing on track for mid-year and phase 1 clinical trial expected third-quarter 2020
WALTHAM, MA, USA I June 29, 2020 I Morphic Therapeutic (NASDAQ: MORF), a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, today announced a presentation highlighting Morphic’s product candidate MORF-057 at the 2020 Digestive Disease Week (DDW) virtual event. The new data presented at DDW expand on Morphic’s recent oral presentation at the 15th Congress of the European Crohn’s and Colitis Organisation (ECCO), which support MORF-057’s development as a potent, selective, and orally available small molecule inhibitor of the integrin α4β7, a validated target for the treatment of inflammatory bowel disease (IBD).
“The data presented at DDW demonstrate that MORF-057 successfully targets the integrin α4β7 with high potency and selectivity. These studies recapitulate results from previous in vitro and in vivo models of increasing complexity and bolster the emerging profile of MORF-057 by demonstrating saturation of α4β7 in non-human primate receptor occupancy studies,” commented Bruce Rogers, Ph.D., chief scientific officer of Morphic Therapeutic. “We believe a safe and effective oral inhibitor of α4β7 would provide a highly differentiated new treatment for IBD and we now look forward to filing the Investigational New Drug Application for MORF-057 and the initiation of clinical studies for this promising drug candidate.”
About the MORF-057 DDW Presentation
The data presented at DDW demonstrate MORF-057’s inhibition of α4β7-expressing lymphocyte migration to the gut, which is a fundamental contributor to IBD. In mice, its inhibitory activity demonstrated potency comparable to an anti-α4β7 antibody. In non-human primate (NHP) models, MORF-057 demonstrated important proof of mechanistic activity by driving accumulation of mucosal homing α4β7-high expressing T cells in the peripheral blood, in an analogous manner to the approved anti-α4β7 antibody, vedolizumab. Importantly, a MORF-057 analog demonstrated >90% receptor occupancy of α4β7 in NHPs, providing an important indicator of the product candidate’s target engagement.
In biochemical assays MORF-057 demonstrated high selectivity over a broad panel of integrins. These results were consistent in cell adhesion assays, where MORF-057 showed greater than 3,000-fold targeted selectivity of α4β7 integrin over its nearest family members, including α4β1. MORF-057 was designed to achieve high selectivity for α4β7 over α4β1 to help prevent unwanted localized immune suppression potentially leading to certain adverse opportunistic infections. In contrast to small molecule or antibody inhibitors of α4β1, a MORF-057 analog did not show a statistically significant increase in lymphocytes in mice in these studies.
Details of the Poster Presentation at DDW 2020:
Title: Preclinical Characterization of an Oral Small Molecule Inhibitor Targeting the Integrin α4β7 for the Treatment of Inflammatory Bowel Diseases (IBD)
Presenter: Dr. Jamie Wong, Ph.D.
Contributors: Jamie Wong, Matthew Bursavich, Natalia Blanco, Adam Camblin, Laura Cappellucci, Rhianna Cohen, Dan Cui, Kris Hahn, Megan Krumpoch, Dooyoung Lee, Fu-Yang Lin, Blaise Lippa, Alex Lugovskoy, Molly McShea, Maloy Mangada, Siavash Mostafavi, Terence Moy, Adrian Ray, Naresh Redhu, Allison Sang, Andrew Sullivan, Peter Traber, Dawn Troast, Cheng Zhong, Liangsu Wang, Bruce Rogers
This DDW presentation is available on the Morphic website on the Investor page.
Morphic is developing MORF-057 as a selective, oral small molecule inhibitor of the α4β7 integrin for patients with inflammatory bowel disease (IBD). α4β7 has been clinically validated as a target for the treatment of IBD by the success of the approved antibody therapeutic vedolizumab. MORF-057 is designed to block the interactions between α4β7 on the surface of lymphocytes and the mucosal endothelial cell ligand MAdCAM-1, preventing lymphocyte migration from the bloodstream into intestinal mucosal tissues and causing inflammation.
About Morphic Therapeutic
Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen, and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.
SOURCE: Morphic Therapeutics