Enzo Biochem Reports Publication of Study on Therapeutic Candidate SK1-I Detailing Promising Results in a Model of Treatment-Resistant Breast Cancer
- Category: Small Molecules
- Published on Tuesday, 04 December 2018 10:56
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Drug Candidate SK1-I Shown to Reverse Tamoxifen Resistance in Human Breast Cancer Preclinical Study
NEW YORK, NY, USA I December 03, 2018 I Enzo Biochem, Inc. (NYSE:ENZ), an integrated diagnostics and therapeutics company, today reported the publication of a study in the Journal of Lipid Research by researchers at a collaborating institution that shows SK1-I, the company’s proprietary Sphingosine Kinase 1 inhibitor drug candidate, was effective in reversing resistance to the breast cancer drug tamoxifen in a tamoxifen-resistant human breast cancer cell line. As pointed out in the publication, endocrine therapy, such as tamoxifen, is a first line treatment for estrogen receptor-positive breast cancer patients. However, more than 50% of patients who initially respond to tamoxifen ultimately fail therapy due to the development of resistance. These results suggest that SK1-I may have potential in the treatment of tamoxifen-resistant breast cancers.
Elazar Rabbani, Ph.D., CEO of Enzo Biochem, Inc. commented: “Regulation of the Sphingosine pathway for the potential treatment of a variety of cancers has become an area of pioneering interest in the field of oncology. Our research results, as well as those of our collaborators, show that SK1-I, Enzo’s proprietary Sphingosine Kinase 1 inhibitor, may address significant unmet medical needs in the treatment of particular oncology indications and immune-related disorders, and warrants further development. We look forward to advancing this therapeutics program in the coming year.”
Sphingosine Kinase 1 is a key enzyme in the Sphingosine pathway that has been implicated in tumor cell growth and pathological inflammation. The enzyme acts by phosphorylating the cellular lipid Sphingosine to Sphingosine 1-Phosphate (S1P), an important biological mediator of tumor cell proliferation and drug resistance in various cancers, and of immune function. SK1-I is a small molecule that specifically inhibits Sphingosine Kinase 1 and has shown anti-cancer activity in various models of hematological cancers, such as Acute Lymphoblastic Leukemia (ALL), and solid tumors, such as glioblastoma.
As a result of Enzo’s research, a novel solid tumor indication for SK1-I has also recently been validated in multiple in vitro human tumor cell line models and is undergoing further development. In further support of this program, Enzo has established in-house GMP manufacturing of SK1-I and is planning to initiate in vivo tumor xenograft studies for the lead solid tumor indication using the GMP-manufactured compound in the near term. The company is also exploring various partnership approaches for the continued development of the compound.
Apart from oncology, in the immunoregulation area, another of Enzo’s research collaborators has shown that SK1-I prevents the induction of Interferon Gamma (IFNγ), a major inflammatory biomarker, in a well-established Concanavalin A (ConA) induced animal model of autoimmune hepatitis.
The compound SK1-I and related compounds, as well as their use in oncology and other therapeutic areas, are covered by a family of issued U.S. patents co-owned by Enzo and Virginia Commonwealth University and exclusively licensed by VCU to Enzo. Foreign patent family members have also issued or been allowed. The basic patent terms of the U.S. patents in this patent family continue into 2029, before possible extensions. On May 22, 2018, the latest patent in this family, U.S. Patent No. 9,974,758, which is directed to methods for treating cancer using SK1-I, was issued.
More recently, the company filed a new family of patent applications, both in the U.S. and internationally, that are directed to novel oncology indications for SK1-I, including the company’s lead solid tumor indication. The basic patent terms for any U.S. patents that may issue from this patent family will continue into 2038, before possible extensions.
Enzo Biochem is a pioneer in molecular diagnostics, leading the convergence of clinical laboratories, life sciences and intellectual property through the development of unique diagnostic platform technologies that provide numerous advantages over previous standards. A global company, Enzo Biochem utilizes cross-functional teams to develop and deploy products, systems and services that meet the ever-changing and rapidly growing needs of health care today and into the future. Underpinning Enzo Biochem’s products and technologies is a broad and deep intellectual property portfolio, with patent coverage across a number of key enabling technologies.
SOURCE: Enzo Biochem