Data Expected in Second Half of 2019
CAMBRIDGE, MA, USA I November 26, 2018 I Evelo Biosciences, Inc. (NASDAQ:EVLO) (“Evelo”) a clinical-stage biotechnology company developing monoclonal microbials to engage immune cells in the small intestine and drive changes in systemic biology, today announced first dosing in its Phase 1b clinical trial of EDP1815 for the treatment of psoriasis and atopic dermatitis. EDP1815 is Evelo’s second monoclonal microbial product candidate being developed for the treatment of inflammatory diseases.
“Psoriasis and atopic dermatitis patients are underserved by current medicines, particularly in the moderate patient populations, where the potential efficacy, tolerability and convenience benefits of monoclonal microbials could be profound,” said Andrea Itano, Ph.D., head of immuno-inflammatory diseases at Evelo. “Monoclonal microbials may also have broader therapeutic applicability for many other inflammatory diseases. Alongside the disease-specific exploratory endpoints for atopic dermatitis and psoriasis, this study will also measure biomarkers such as Th1, Th2 and Th17, which may help define the potential for EDP1815 to treat a broader range atopic and arthritic diseases.”
About Clinical Trial EDP1815-101
EDP1815-101 is a placebo-controlled Phase 1b that will investigate the safety and tolerability of EDP1815 in 96 healthy volunteers and in patients with mild or moderate psoriasis or atopic dermatitis. Exploratory endpoints include the effect of EDP1815 on validated clinical measures of disease and a range of additional pharmacodynamic markers. Evelo expects to report initial clinical data from this trial in the second half of 2019.
About Evelo Biosciences
Evelo Biosciences, Inc. is a clinical-stage biotechnology company developing monoclonal microbials, a new modality of medicines designed to act on the gut-body network. Evelo’s product candidates are orally-delivered, single strains of microbes, selected for defined pharmacological properties. They are intended to modulate systemic immunology and biology by acting on multiple naturally evolved biological pathways that link the small intestine to the rest of the body. Evelo believes that monoclonal microbials have the potential to be broadly applicable across many diseases including inflammation, cancer and autoimmune diseases.
Evelo currently has three product candidates, EDP1066 and EDP1815 for the treatment of inflammatory diseases and EDP1503 for the treatment of cancer, for which ten clinical readouts are expected during 2019 and 2020. Evelo is also advancing additional candidates through preclinical development in other disease areas.
For more information, please visit www.evelobio.com.
SOURCE: Evelo Biosciences
Post Views: 29
Data Expected in Second Half of 2019
CAMBRIDGE, MA, USA I November 26, 2018 I Evelo Biosciences, Inc. (NASDAQ:EVLO) (“Evelo”) a clinical-stage biotechnology company developing monoclonal microbials to engage immune cells in the small intestine and drive changes in systemic biology, today announced first dosing in its Phase 1b clinical trial of EDP1815 for the treatment of psoriasis and atopic dermatitis. EDP1815 is Evelo’s second monoclonal microbial product candidate being developed for the treatment of inflammatory diseases.
“Psoriasis and atopic dermatitis patients are underserved by current medicines, particularly in the moderate patient populations, where the potential efficacy, tolerability and convenience benefits of monoclonal microbials could be profound,” said Andrea Itano, Ph.D., head of immuno-inflammatory diseases at Evelo. “Monoclonal microbials may also have broader therapeutic applicability for many other inflammatory diseases. Alongside the disease-specific exploratory endpoints for atopic dermatitis and psoriasis, this study will also measure biomarkers such as Th1, Th2 and Th17, which may help define the potential for EDP1815 to treat a broader range atopic and arthritic diseases.”
About Clinical Trial EDP1815-101
EDP1815-101 is a placebo-controlled Phase 1b that will investigate the safety and tolerability of EDP1815 in 96 healthy volunteers and in patients with mild or moderate psoriasis or atopic dermatitis. Exploratory endpoints include the effect of EDP1815 on validated clinical measures of disease and a range of additional pharmacodynamic markers. Evelo expects to report initial clinical data from this trial in the second half of 2019.
About Evelo Biosciences
Evelo Biosciences, Inc. is a clinical-stage biotechnology company developing monoclonal microbials, a new modality of medicines designed to act on the gut-body network. Evelo’s product candidates are orally-delivered, single strains of microbes, selected for defined pharmacological properties. They are intended to modulate systemic immunology and biology by acting on multiple naturally evolved biological pathways that link the small intestine to the rest of the body. Evelo believes that monoclonal microbials have the potential to be broadly applicable across many diseases including inflammation, cancer and autoimmune diseases.
Evelo currently has three product candidates, EDP1066 and EDP1815 for the treatment of inflammatory diseases and EDP1503 for the treatment of cancer, for which ten clinical readouts are expected during 2019 and 2020. Evelo is also advancing additional candidates through preclinical development in other disease areas.
For more information, please visit www.evelobio.com.
SOURCE: Evelo Biosciences
Post Views: 29
