Development in Parkinson’s Disease Cognitive Impairment Planned
EVANSTON, IL, USA I August 02, 2018 I Aptinyx Inc. (NASDAQ:APTX), a clinical-stage biopharmaceutical company developing transformative therapies for the treatment of brain and nervous system disorders, today announced initiation of Phase 1 clinical development of NYX-458, its third novel product candidate that modulates N-methyl-D-aspartate (NMDA) receptors.
The randomized, double-blind, placebo-controlled Phase 1 study will enroll approximately 62 healthy volunteers to evaluate the safety, tolerability, and pharmacokinetics of single and repeat dosing of NYX-458 at multiple dose levels. Aptinyx intends to develop NYX-458 for the treatment of cognitive impairment associated with Parkinson’s disease and plans to advance the compound into studies to evaluate efficacy next year.
“Based on the compelling preclinical evidence of NYX-458 in reversing cognitive impairment, we are excited to initiate this first-in-human study and advance NYX-458 as a potential treatment for this very common and highly limiting, but poorly treated, symptom of Parkinson’s disease,” said Torsten Madsen, M.D., Ph.D., chief medical officer of Aptinyx. “With NYX-458, we now have three product candidates in clinical development, further demonstrating the broad applicability of our discovery platform.”
Through NMDA receptor modulation, NYX-458 enhances synaptic plasticity to improve neural cell communication, which may translate into improvements in learning, memory, and cognition, the deterioration of which is increasingly recognized as a major component of Parkinson’s disease.
Aptinyx’s chemistry and discovery platform has generated numerous novel small-molecule modulators of the NMDA receptor, including the company’s three product candidates in clinical development, NYX-2925, NYX-783, and NYX-458. In studies to date, these molecules have demonstrated high oral bioavailability, diverse NMDA receptor subtype binding profiles and pharmacology, and differentiated efficacy in preclinical models of various nervous system conditions.
About Aptinyx
Aptinyx Inc. is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of proprietary synthetic small molecules for the treatment of brain and nervous system disorders. Aptinyx has a platform for discovery of novel compounds that work through a unique mechanism to modulate – rather than block or over-activate – NMDA receptors and enhance synaptic plasticity, the foundation of neural cell communication. The company has three product candidates in clinical development for the treatment of chronic pain, post-traumatic stress disorder (PTSD), and cognitive impairment associated with Parkinson’s disease. Aptinyx is also advancing additional compounds from its proprietary discovery platform, which continues to generate a rich and diverse pipeline of small-molecule NMDA receptor modulators with the potential to treat an array of neurologic disorders. For more information, visit www.aptinyx.com.
SOURCE: Aptinyx
Post Views: 20
Development in Parkinson’s Disease Cognitive Impairment Planned
EVANSTON, IL, USA I August 02, 2018 I Aptinyx Inc. (NASDAQ:APTX), a clinical-stage biopharmaceutical company developing transformative therapies for the treatment of brain and nervous system disorders, today announced initiation of Phase 1 clinical development of NYX-458, its third novel product candidate that modulates N-methyl-D-aspartate (NMDA) receptors.
The randomized, double-blind, placebo-controlled Phase 1 study will enroll approximately 62 healthy volunteers to evaluate the safety, tolerability, and pharmacokinetics of single and repeat dosing of NYX-458 at multiple dose levels. Aptinyx intends to develop NYX-458 for the treatment of cognitive impairment associated with Parkinson’s disease and plans to advance the compound into studies to evaluate efficacy next year.
“Based on the compelling preclinical evidence of NYX-458 in reversing cognitive impairment, we are excited to initiate this first-in-human study and advance NYX-458 as a potential treatment for this very common and highly limiting, but poorly treated, symptom of Parkinson’s disease,” said Torsten Madsen, M.D., Ph.D., chief medical officer of Aptinyx. “With NYX-458, we now have three product candidates in clinical development, further demonstrating the broad applicability of our discovery platform.”
Through NMDA receptor modulation, NYX-458 enhances synaptic plasticity to improve neural cell communication, which may translate into improvements in learning, memory, and cognition, the deterioration of which is increasingly recognized as a major component of Parkinson’s disease.
Aptinyx’s chemistry and discovery platform has generated numerous novel small-molecule modulators of the NMDA receptor, including the company’s three product candidates in clinical development, NYX-2925, NYX-783, and NYX-458. In studies to date, these molecules have demonstrated high oral bioavailability, diverse NMDA receptor subtype binding profiles and pharmacology, and differentiated efficacy in preclinical models of various nervous system conditions.
About Aptinyx
Aptinyx Inc. is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of proprietary synthetic small molecules for the treatment of brain and nervous system disorders. Aptinyx has a platform for discovery of novel compounds that work through a unique mechanism to modulate – rather than block or over-activate – NMDA receptors and enhance synaptic plasticity, the foundation of neural cell communication. The company has three product candidates in clinical development for the treatment of chronic pain, post-traumatic stress disorder (PTSD), and cognitive impairment associated with Parkinson’s disease. Aptinyx is also advancing additional compounds from its proprietary discovery platform, which continues to generate a rich and diverse pipeline of small-molecule NMDA receptor modulators with the potential to treat an array of neurologic disorders. For more information, visit www.aptinyx.com.
SOURCE: Aptinyx
Post Views: 20
