PL-8177 Evaluated in Animal Models of Inflammatory Bowel Disease and Autoimmune Uveitis; PL-8331 Evaluated in an Animal Model of Dry Eye
CRANBURY, NJ, USA I May 9, 2018 I Palatin Technologies, Inc. (NYSE American: PTN), a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet medical needs and commercial potential, announced today a poster presentation on its PL-8177 and PL-8331 melanocortin-1 receptor agonist programs. PL-8177 is Palatin’s lead clinical product candidate for the treatment of inflammatory bowel disease, including Crohn’s disease. PL-8331 is the Company’s drug candidate for the treatment of dry eye. The poster presentation will be made at the TIDES: Oligonucleotide and Peptide Therapeutics 2018 meeting in Boston, Massachusetts on May 9, 2018.
“Now that a New Drug Application has been submitted on bremelanotide for hypoactive sexual desire disorder, Palatin is focused on expanding indications for our melanocortin and natriuretic peptide technologies,” said Carl Spana, Ph.D., CEO and President of Palatin. “We believe that that our receptor-specific peptide and small molecule melanocortin therapeutics can address a number of important diseases that are currently underserved.”
The poster entitled “Probing the Role of the MC1 Receptor Agonists in Diverse Immunological Diseases,” highlights data from preclinical studies with two proprietary peptide agonists developed by Palatin, PL-8177 and PL-8331. The poster can be found on the Palatin website at https://www.palatin.com/resources/corporate-presentation/poster-presentations/.
Data from a rat model of bowel inflammation showed reduced inflammation and colon weight scores to a similar degree as sulfasalazine, the positive control drug. PL-8177 was also evaluated in a mouse model of autoimmune uveitis. In this model, PL-8177 administered by intraperitoneal injection demonstrated significantly reduced retinal inflammation compared to untreated controls. PL-8177 is in ongoing Phase 1 safety studies.
PL-8331 was evaluated in a mouse model of dry eye. In this model PL-8331 demonstrated reduction in corneal epithelial damage due to dry eye with efficacy similar to Restasis® cyclosporine ophthalmic emulsion. Palatin anticipates completing Investigational New Drug preclinical enabling activities on PL-8331 later this calendar year.
The TIDES: Oligonucleotide and Peptide Therapeutics 2018 meeting is May 7-10 at the Hynes Convention Center, Boston, MA. For more information, see https://lifesciences.knect365.com/tides/.
About Palatin Technologies
Palatin Technologies, Inc. is a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet medical need and commercial potential. Palatin’s strategy is to develop products and then form marketing collaborations with industry leaders in order to maximize their commercial potential. For additional information regarding Palatin, please visit Palatin’s website at www.Palatin.com.
SOURCE: Palatin Technologies
Post Views: 34
PL-8177 Evaluated in Animal Models of Inflammatory Bowel Disease and Autoimmune Uveitis; PL-8331 Evaluated in an Animal Model of Dry Eye
CRANBURY, NJ, USA I May 9, 2018 I Palatin Technologies, Inc. (NYSE American: PTN), a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet medical needs and commercial potential, announced today a poster presentation on its PL-8177 and PL-8331 melanocortin-1 receptor agonist programs. PL-8177 is Palatin’s lead clinical product candidate for the treatment of inflammatory bowel disease, including Crohn’s disease. PL-8331 is the Company’s drug candidate for the treatment of dry eye. The poster presentation will be made at the TIDES: Oligonucleotide and Peptide Therapeutics 2018 meeting in Boston, Massachusetts on May 9, 2018.
“Now that a New Drug Application has been submitted on bremelanotide for hypoactive sexual desire disorder, Palatin is focused on expanding indications for our melanocortin and natriuretic peptide technologies,” said Carl Spana, Ph.D., CEO and President of Palatin. “We believe that that our receptor-specific peptide and small molecule melanocortin therapeutics can address a number of important diseases that are currently underserved.”
The poster entitled “Probing the Role of the MC1 Receptor Agonists in Diverse Immunological Diseases,” highlights data from preclinical studies with two proprietary peptide agonists developed by Palatin, PL-8177 and PL-8331. The poster can be found on the Palatin website at https://www.palatin.com/resources/corporate-presentation/poster-presentations/.
Data from a rat model of bowel inflammation showed reduced inflammation and colon weight scores to a similar degree as sulfasalazine, the positive control drug. PL-8177 was also evaluated in a mouse model of autoimmune uveitis. In this model, PL-8177 administered by intraperitoneal injection demonstrated significantly reduced retinal inflammation compared to untreated controls. PL-8177 is in ongoing Phase 1 safety studies.
PL-8331 was evaluated in a mouse model of dry eye. In this model PL-8331 demonstrated reduction in corneal epithelial damage due to dry eye with efficacy similar to Restasis® cyclosporine ophthalmic emulsion. Palatin anticipates completing Investigational New Drug preclinical enabling activities on PL-8331 later this calendar year.
The TIDES: Oligonucleotide and Peptide Therapeutics 2018 meeting is May 7-10 at the Hynes Convention Center, Boston, MA. For more information, see https://lifesciences.knect365.com/tides/.
About Palatin Technologies
Palatin Technologies, Inc. is a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet medical need and commercial potential. Palatin’s strategy is to develop products and then form marketing collaborations with industry leaders in order to maximize their commercial potential. For additional information regarding Palatin, please visit Palatin’s website at www.Palatin.com.
SOURCE: Palatin Technologies
Post Views: 34
