Morphotek Announces Agreement to License its Proprietary Eribulin-Linker Payload to Bliss Biopharmaceutical Co., Ltd. for Development of a Therapeutic Antibody-Drug Conjugate (ADC)

EXTON, PA, USA I April 9, 2018 I Morphotek®, Inc., a subsidiary of Eisai Inc., announced today that it licensed its eribulin-linker payload to Bliss Biopharmaceutical Co., Ltd. (BlissBio) of China.  The licensing agreement grants BlissBio the exclusive right to use the eribulin-linker payload to develop a therapeutic ADC against an undisclosed oncology target for the China market.  The licensing agreement includes an upfront payment, milestones and sales royalty payments, which are undisclosed.  BlissBio has an exclusivity option to expand the territory beyond China to the global market and to develop therapeutic ADCs to two additional undisclosed oncology targets.

Morphotek's ADC Services offer third parties the opportunity to license the proprietary eribulin-linker payload to develop investigational ADCs using either Morphotek's REsidue-SPEcific Conjugation Technology (RESPECT™) or an alternative approach to conjugation.  The eribulin-linker payload consists of a cytotoxic agent, eribulin, modified by a chemical linker to facilitate optimal conjugation.  Eribulin's anti-tumor activity is mediated by the inhibition of microtubule elongation and mitotic spindle formation, resulting in apoptosis.  Eribulin mesylate, marketed as Halaven®, is approved in the U.S. for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for metastatic disease, including an anthracycline and a taxane in either the adjuvant or metastatic setting. 

Our end-to-end ADC Services provide multiple entry points for clients, starting from development of an antigen site-specific bioconjugate-ready monoclonal antibody and ADC through in vivo safety and efficacy validation.  Additional options include manufacture of GMP clinical trial material, GLP toxicology studies and development of immunohistochemistry (IHC) companion diagnostics for patient screening.  For more information on Morphotek's ADC Services business and RESPECT platform, please contact This email address is being protected from spambots. You need JavaScript enabled to view it..

*The ADCs described herein are investigational, as efficacy and safety have not been established.  There is no guarantee that the ADCs will be available commercially.

About Morphotek

Morphotek®, Inc., a subsidiary of Eisai Inc., is a clinical-stage biotechnology company focused on developing novel classes of biological-based products to treat cancer, inflammatory and infectious diseases.  Our mission is to develop novel targeted therapies that attack underlying disease pathways, and in oncology indications, that can overcome the immunosuppressive effects by tumors on immune-mediated experimental therapies.  Our diverse pipeline includes clinical-stage monoclonal antibodies to lead targets folate receptor alpha, mesothelin and endosialin, as well as antibody-drug conjugates and bispecific antibodies to undisclosed targets in preclinical development.  Our mission is supported by proprietary cutting-edge technologies in antibody engineering, manufacturing and screening optimization platforms, along with our expertise in developing diagnostics to support patient selection and therapeutic strategy.  For more information, please visit

About Bliss Biopharmaceutical Co., Ltd.

Bliss Biopharmaceutical (Hangzhou) Co. Ltd. is a biopharmaceutical company focusing on discovery, development and commercialization of biotherapeutics for unmet medical needs. It is located in the high-tech enterprises in Hangzhou Economic and Technological Development Park in Hangzhou, Zhejiang province, China, and jointly established by a number of biopharmaceutical leaders returned to China from overseas, each with over 20 years of industrial experience.  Its mission is to unite and bring to life the ideas and strengths of hundreds of collaborators to advance product pipeline and improve human health.  The company has developed a rich pipeline engaging multiple technology platforms through collaborations with domestic and foreign biopharmaceutical companies.  BlissBio has completed its first round of financing led by acclaimed venture capital firm, Oriental Fortune Capital, and it is rapidly advancing multiple products through different development stages. 

About Eisai Inc.

At Eisai Inc., human health care (hhc) is our goal. We give our first thought to patients and their families, and helping to increase the benefits health care provides. As the U.S. pharmaceutical subsidiary of Tokyo-based Eisai Co., Ltd., we have a passionate commitment to patient care that is the driving force behind our efforts to discover and develop innovative therapies to help address unmet medical needs.

Eisai is a fully integrated pharmaceutical business that operates in two global business groups: oncology and neurology (dementia-related diseases and neurodegenerative diseases).  Each group functions as an end-to-end global business with discovery, development, and marketing capabilities. Our U.S. headquarters, commercial and clinical development organizations are located in New Jersey; our discovery labs are in Massachusetts and Pennsylvania; and our global demand chain organization resides in Maryland and North Carolina. To learn more about Eisai Inc., please visit us at and follow us on Twitter and LinkedIn.

About Halaven® (eribulin mesylate) Injection

Halaven® (eribulin mesylate) is a microtubule dynamics inhibitor indicated for the treatment of patients with:

  • Metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease.  Prior therapy should have included an anthracycline and a taxane in either the adjuvant or metastatic setting.
  • Unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen.

Discovered and developed by Eisai, eribulin is a synthetic analog of halichondrin B, a natural product that was isolated from the marine sponge Halichondria okadai.  First in the halichondrin class, Halaven is a microtubule dynamics inhibitor.  Eribulin is believed to work primarily via a tubulin-based mechanism that causes prolonged and irreversible mitotic blockage, ultimately leading to apoptotic cell death.  Additionally, in preclinical studies of human breast cancer, eribulin demonstrated complex effects on the tumor biology of surviving cancer cells, including increases in vascular perfusion resulting in reduced tumor hypoxia, and changes in the expression of genes in tumor specimens associated with a change in phenotype, promoting the epithelial phenotype, opposing the mesenchymal phenotype.  Eribulin has also been shown to decrease the migration and invasiveness of human breast cancer cells.  Halaven is approved in approximately 60 countries worldwide. 

SOURCE: Morphotek

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