Agenus Commences Phase 1 Trial with Neoantigen Cancer Vaccine AutoSynVax
- Category: Vaccines
- Published on Thursday, 06 April 2017 09:36
- Hits: 2411
LEXINGTON, MA, USA I April 5, 2017 I Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with a clinical stage pipeline of immune checkpoint antibodies and cancer vaccines, today announced that the first patient has been dosed in a Phase 1 clinical trial of AutoSynVax™ (ASV™), Agenus' neoantigen vaccine. Preclinical data presented at the American Association for Cancer Research (AACR) 2017 Annual Meeting show ASV to be active and synergistic with checkpoint blockade.
The open-label trial will test the ASV vaccine in combination with QS-21 Stimulon® adjuvant in patients with advanced cancer. The trial is intended to pave the way for further evaluation of combinations of ASV with Agenus' checkpoint antibodies targeting CTLA-4 and PD-1.
"AutoSynVax is one of three vaccine platforms proprietary to Agenus that have the potential to expand cancer patient populations that benefit from immunotherapy," said Dr. John Castle, Ph.D., Senior Director Computational Biology and Genomics at Agenus. "Our innovative algorithms, clinically validated HSP-based antigenic peptide delivery system, QS-21 Stimulon, and a portfolio of checkpoint antibodies place us in a uniquely advantageous position to potentially treat patients with advanced malignancies." Dr. Castle is the lead author of pioneering research1 that demonstrated feasibility of identifying neoantigen immunogens that evoke anti-tumor immunity.
This week at AACR Agenus scientists presented evidence that ASV mediates tumor control and lasting immune memory in murine models of cancer. Additional data indicated that ASV cooperates with a surrogate CTLA-4 targeted antibody to bolster anti-tumor immunity in a mouse model of melanoma.
ASV is a personalized cancer vaccine platform that involves identification of tumor neoantigens unique to each patient using genomic sequencing. Each tumor mutational signature is interrogated using advanced bioinformatics algorithms derived from mass spectrometry profiling and structural biology modeling to catalogue and rank the tumor antigens that arise from these mutations. Neoantigens computationally predicted to be most immunogenic are incorporated into the so-called vaccine 'blueprint', synthesized, complexed with heat shock proteins (HSPs) and administered in conjunction with QS-21 Stimulon, Agenus' proprietary adjuvant. The HSP-peptide complexes accompanied by QS-21 Stimulon are designed to be efficient activators of T cells specific to the tumor neoepitopes and can elicit tumor control. Their activity is expected to be further enhanced by combinations with checkpoint modulators, such as our clinical-stage CTLA-4 (AGEN1884) and PD-1 (AGEN2034) antagonists, as confirmed by the preclinical data presented at AACR. The ASV platform could be applicable to a broad range of tumors.
Additional information about the trial can be found here.
1. Castle JC, Kreiter S, Diekmann J, Löwer M, van de Roemer N, de Graaf J, Selmi A, Diken M, Boegel S, Paret C, Koslowski M, Kuhn AN, Britten CM, Huber C, Türeci O, Sahin U. Exploiting the mutanome for tumor vaccination. Cancer Res. 2012; 72(5): 1081-91.
Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing a number of combination approaches that leverage a broad repertoire of antibody therapeutics and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support early phase clinical programs. Agenus is based in Lexington, MA. For more information, please visit www.agenusbio.com; information that may be important to investors will be routinely posted on our website.