Nuvelo Announces Publication of NU206 Study Results in Proceedings of the National Academy of Sciences of the United States of America

Nuvelo, Inc. today announced the publication of data from a study of preclinical candidate NU206

SAN CARLOS, CA, USA | September 27, 2007 |
Nuvelo, Inc. (Nasdaq: NUVO) today announced the publication of data from a study of preclinical candidate, NU206 (R-Spondin1), describing the mechanism which regulates the Wnt pathway. By increasing the cell surface levels of low-density lipoprotein-receptor-related protein 6 (LRP6), NU206 is able to stimulate the Wnt pathway, a signaling pathway that is critical for cell growth and differentiation during homeostasis and pathogenesis. The study, entitled "R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6," appears in the September 11th issue of Proceedings of the National Academy of Sciences of the United States of America (PNAS).

"This study expands our understanding of the link between NU206 and the Wnt signaling pathway," said Michael Levy, executive vice president of research and development for Nuvelo. "In addition to NU206, we are assessing the therapeutic potential of the RSpondin family of secreted proteins in our Wnt therapeutics program, which is targeting a range of indications where cell regeneration and differentiation are important to disease processes, including gastrointestinal disease, bone disorders, wound healing and cancer."

About NU206 and R-Spondin secreted proteins

NU206 (R-spondin1) is a recombinant, secreted protein that acts as a highly specific regulator of the gastrointestinal (GI) epithelial cells as demonstrated in early animal studies. Preclinical studies suggest it can promote growth and tissue regeneration in animal models of radiation treatment or chemotherapy for cancer, as well as in animal models of inflammatory bowel disease.

The R-Spondin (RSpo) family of secreted proteins are the first biologic agents that can be used to enhance endogenous Wnt signaling in vivo, and provide therapeutic potential in diseases that are dependent on the Wnt pathway for restoration of homeostasis or tissue repair. RSpo proteins are novel regulators of the Wnt pathway and were first identified by Nuvelo as potent gastrointestinal mitogens in transgenic mice(1).

About Nuvelo and Kirin's Joint Collaborative Effort

Scientists from Nuvelo and Kirin worked together to identify and characterize NU206 as part of a collaboration focused on the discovery of novel, secreted proteins. NU206 is the first compound to enter preclinical studies from this program. Nuvelo signed a collaboration agreement with Kirin in April 2005 to develop NU206. Under the agreement, Nuvelo leads worldwide development, manufacturing and commercialization and all operating expenses and profits related to the development and commercialization of NU206 are shared 60% (Nuvelo)/40% (Kirin).

About Nuvelo

Nuvelo, Inc. is dedicated to improving the lives of patients through the discovery, development and commercialization of novel drugs for acute cardiovascular disease, cancer and other debilitating medical conditions. Nuvelo's development pipeline includes alfimeprase, a direct acting fibrinolytic in Phase 2 clinical development for the treatment of thrombotic-related disorders including acute ischemic stroke and catheter occlusion; and preclinical candidates NU206 for the potential treatment of chemotherapy/radiation therapy-induced mucositis and inflammatory bowel disease and NU172, a direct thrombin inhibitor for use as a potential short-acting anticoagulant during medical or surgical procedures. In addition, Nuvelo expects to leverage its expertise in leukemia therapeutic antibody and Wnt signaling pathway research to further expand its pipeline and create additional partnering and licensing opportunities.

(1) Kim et al. (2005) Mitogenic influence of human R-Spondin1 on the intestinal epithelium. Science 309.

SOURCE: Nuvelo, Inc.

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