- Novel target class with dual action in inflammatory disorders
- Discovered and validated on Galapagos’ target discovery platform
- Fully owned and proprietary
MECHELEN, Belgium I January 7, 2019 I Galapagos NV (Euronext & NASDAQ: GLPG) initiated a Phase 1 trial with GLPG3312, a first generation compound against a novel and undisclosed inflammation target class discovered by Galapagos.
The Phase 1 trial is a double-blind, placebo-controlled, single-center study evaluating the efficacy, safety, tolerability, and PK/PD[1] of GLPG3312 in 76 adult healthy male volunteers.
“We are excited by the rapid progression of our Toledo program into the clinic,” said Dr. Piet Wigerinck, Chief Scientific Officer at Galapagos. “Thanks to its unique mechanism of action, the Toledo program has the potential to become a new paradigm in the treatment of inflammatory diseases.”
About Toledo
“Toledo” is a code name for a novel class discovered by Galapagos. The target family has a dual mode of action on inflammation by stimulating anti-inflammatory cytokines and inhibiting pro-inflammatory cytokines. We have observed unprecedented activity in various inflammatory preclinical models with compounds targeting the class. Galapagos is executing on a broad program to discover and develop multiple series of compounds acting on Toledo, aimed at activity across several inflammatory conditions.
GLPG3312 is an investigational drug and its efficacy and safety have not been established.
More information about Toledo can be found in our R&D Update 2018: www.glpg.com/webcasts.
For information about the clinical trial with GLPG3312: www.clinicaltrials.gov.
About Galapagos
Galapagos (Euronext & NASDAQ: GLPG) discovers and develops small molecule medicines with novel modes of action, three of which show promising patient results and are currently in late-stage development in multiple diseases. Our pipeline comprises Phase 3 through to discovery programs in inflammation, fibrosis, osteoarthritis and other indications. Our ambition is to become a leading global biopharmaceutical company focused on the discovery, development and commercialization of innovative medicines. More information at www.glpg.com.
SOURCE: Galapagos
Post Views: 117
- Novel target class with dual action in inflammatory disorders
- Discovered and validated on Galapagos’ target discovery platform
- Fully owned and proprietary
MECHELEN, Belgium I January 7, 2019 I Galapagos NV (Euronext & NASDAQ: GLPG) initiated a Phase 1 trial with GLPG3312, a first generation compound against a novel and undisclosed inflammation target class discovered by Galapagos.
The Phase 1 trial is a double-blind, placebo-controlled, single-center study evaluating the efficacy, safety, tolerability, and PK/PD[1] of GLPG3312 in 76 adult healthy male volunteers.
“We are excited by the rapid progression of our Toledo program into the clinic,” said Dr. Piet Wigerinck, Chief Scientific Officer at Galapagos. “Thanks to its unique mechanism of action, the Toledo program has the potential to become a new paradigm in the treatment of inflammatory diseases.”
About Toledo
“Toledo” is a code name for a novel class discovered by Galapagos. The target family has a dual mode of action on inflammation by stimulating anti-inflammatory cytokines and inhibiting pro-inflammatory cytokines. We have observed unprecedented activity in various inflammatory preclinical models with compounds targeting the class. Galapagos is executing on a broad program to discover and develop multiple series of compounds acting on Toledo, aimed at activity across several inflammatory conditions.
GLPG3312 is an investigational drug and its efficacy and safety have not been established.
More information about Toledo can be found in our R&D Update 2018: www.glpg.com/webcasts.
For information about the clinical trial with GLPG3312: www.clinicaltrials.gov.
About Galapagos
Galapagos (Euronext & NASDAQ: GLPG) discovers and develops small molecule medicines with novel modes of action, three of which show promising patient results and are currently in late-stage development in multiple diseases. Our pipeline comprises Phase 3 through to discovery programs in inflammation, fibrosis, osteoarthritis and other indications. Our ambition is to become a leading global biopharmaceutical company focused on the discovery, development and commercialization of innovative medicines. More information at www.glpg.com.
SOURCE: Galapagos
Post Views: 117