Preclinical data demonstrate ATYR0101’s unique anti-fibrotic mechanism through interaction with LTBP-1.
ATYR0101 to be showcased in oral presentation at the American Thoracic Society (ATS) 2025 Respiratory Innovation Summit.
SAN DIEGO, CA, USA I May 14, 2025 I aTyr Pharma, Inc. (Nasdaq: ATYR) (“aTyr” or the “Company”), a clinical stage biotechnology company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, today announced that it has advanced its next investigational new drug (IND) candidate, ATYR0101, which has been selected to be showcased in an oral presentation at the American Thoracic Society (ATS) 2025 Respiratory Innovation Summit, which is scheduled to take place May 16 – 17, 2025, in San Francisco, CA.
The presentation will feature preclinical data generated to date for ATYR0101, a fusion protein derived from a proprietary extracellular domain of aspartyl-tRNA synthetase (DARS) that binds to latent transforming growth factor beta binding protein 1 (LTBP-1) to induce cell death of myofibroblasts, which are key cells responsible for driving the progression of fibrosis.
“Fibrosis is a key driver of morbidity and mortality in many diseases, particularly those affecting the lung, where evasion of myofibroblast cell death is a defining feature,” said Leslie A. Nangle, Ph.D., Vice President, Research, at aTyr. “The unique effects observed with ATYR0101 in preclinical models of fibrosis suggest it may have the potential to reverse fibrosis, which could represent a meaningful advancement in the approach to treating pulmonary fibrosis, where current treatments only slow disease progression.”
President and Chief Executive Officer of aTyr, Sanjay S. Shukla, M.D., M.S., added, “Building on the promising clinical results of our lead tRNA synthetase-derived therapy, efzofitimod, in interstitial lung disease, we’re excited to advance ATYR0101 into IND-enabling studies. This next candidate from our pipeline exemplifies the transformative potential of our innovative drug discovery platform and highlights our unwavering commitment to pioneering therapies for inflammatory and fibrotic diseases. We look forward to further exploring this candidate in pulmonary fibrosis and anticipate filing an IND application in the second half of 2026.”
Details of the presentation appear below. The presentation will be available on the aTyr website once presented.
Title: ATYR0101: A New Approach to Fibrosis
Presenter: Ryan Adams, Ph.D., Senior Director, In Vitro Biology
Session: Showcase Three: ILD/Fibrosis
Date and Time: Saturday, May 17, 2025 at 11:30 AM PT
Location: San Francisco Marriott Marquis, San Francisco, CA
About ATYR0101
ATYR0101 is a fusion protein derived from a proprietary extracellular domain of aspartyl-tRNA synthetase (DARS) that binds to latent transforming growth factor beta binding protein 1 (LTBP-1) to induce myofibroblast apoptosis. ATYR0101 interacts with LTBP-1 through a unique way that presents a differentiated approach to targeting fibrosis. ATYR0101 has demonstrated anti-fibrotic effects in models of lung and kidney fibrosis suggesting it may have broad therapeutic potential in multiple fibrotic diseases. ATYR0101 is currently undergoing IND-enabling studies.
About aTyr
aTyr is a clinical stage biotechnology company leveraging evolutionary intelligence to translate tRNA synthetase biology into new therapies for fibrosis and inflammation. tRNA synthetases are ancient, essential proteins that have evolved novel domains that regulate diverse pathways extracellularly in humans. aTyr’s discovery platform is focused on unlocking hidden therapeutic intervention points by uncovering signaling pathways driven by its proprietary library of domains derived from all 20 tRNA synthetases. aTyr’s lead therapeutic candidate is efzofitimod, a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease, a group of immune-mediated disorders that can cause inflammation and progressive fibrosis, or scarring, of the lungs. For more information, please visit www.atyrpharma.com.
SOURCE: aTyr
Post Views: 2,796
Preclinical data demonstrate ATYR0101’s unique anti-fibrotic mechanism through interaction with LTBP-1.
ATYR0101 to be showcased in oral presentation at the American Thoracic Society (ATS) 2025 Respiratory Innovation Summit.
SAN DIEGO, CA, USA I May 14, 2025 I aTyr Pharma, Inc. (Nasdaq: ATYR) (“aTyr” or the “Company”), a clinical stage biotechnology company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, today announced that it has advanced its next investigational new drug (IND) candidate, ATYR0101, which has been selected to be showcased in an oral presentation at the American Thoracic Society (ATS) 2025 Respiratory Innovation Summit, which is scheduled to take place May 16 – 17, 2025, in San Francisco, CA.
The presentation will feature preclinical data generated to date for ATYR0101, a fusion protein derived from a proprietary extracellular domain of aspartyl-tRNA synthetase (DARS) that binds to latent transforming growth factor beta binding protein 1 (LTBP-1) to induce cell death of myofibroblasts, which are key cells responsible for driving the progression of fibrosis.
“Fibrosis is a key driver of morbidity and mortality in many diseases, particularly those affecting the lung, where evasion of myofibroblast cell death is a defining feature,” said Leslie A. Nangle, Ph.D., Vice President, Research, at aTyr. “The unique effects observed with ATYR0101 in preclinical models of fibrosis suggest it may have the potential to reverse fibrosis, which could represent a meaningful advancement in the approach to treating pulmonary fibrosis, where current treatments only slow disease progression.”
President and Chief Executive Officer of aTyr, Sanjay S. Shukla, M.D., M.S., added, “Building on the promising clinical results of our lead tRNA synthetase-derived therapy, efzofitimod, in interstitial lung disease, we’re excited to advance ATYR0101 into IND-enabling studies. This next candidate from our pipeline exemplifies the transformative potential of our innovative drug discovery platform and highlights our unwavering commitment to pioneering therapies for inflammatory and fibrotic diseases. We look forward to further exploring this candidate in pulmonary fibrosis and anticipate filing an IND application in the second half of 2026.”
Details of the presentation appear below. The presentation will be available on the aTyr website once presented.
Title: ATYR0101: A New Approach to Fibrosis
Presenter: Ryan Adams, Ph.D., Senior Director, In Vitro Biology
Session: Showcase Three: ILD/Fibrosis
Date and Time: Saturday, May 17, 2025 at 11:30 AM PT
Location: San Francisco Marriott Marquis, San Francisco, CA
About ATYR0101
ATYR0101 is a fusion protein derived from a proprietary extracellular domain of aspartyl-tRNA synthetase (DARS) that binds to latent transforming growth factor beta binding protein 1 (LTBP-1) to induce myofibroblast apoptosis. ATYR0101 interacts with LTBP-1 through a unique way that presents a differentiated approach to targeting fibrosis. ATYR0101 has demonstrated anti-fibrotic effects in models of lung and kidney fibrosis suggesting it may have broad therapeutic potential in multiple fibrotic diseases. ATYR0101 is currently undergoing IND-enabling studies.
About aTyr
aTyr is a clinical stage biotechnology company leveraging evolutionary intelligence to translate tRNA synthetase biology into new therapies for fibrosis and inflammation. tRNA synthetases are ancient, essential proteins that have evolved novel domains that regulate diverse pathways extracellularly in humans. aTyr’s discovery platform is focused on unlocking hidden therapeutic intervention points by uncovering signaling pathways driven by its proprietary library of domains derived from all 20 tRNA synthetases. aTyr’s lead therapeutic candidate is efzofitimod, a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease, a group of immune-mediated disorders that can cause inflammation and progressive fibrosis, or scarring, of the lungs. For more information, please visit www.atyrpharma.com.
SOURCE: aTyr
Post Views: 2,796
