Preclinical Data Published in the International Journal of Obesity
SOUTH SAN FRANCISCO, CA, USA I October 05, 2015 I Atara Biotherapeutics, Inc. (ATRA), a biopharmaceutical company with a focus on developing innovative therapies for patients with debilitating diseases, today announced the publication of preclinical data that provide insight into the pharmacology of its clinical stage anti-myostatin peptibody, PINTA 745.
In the International Journal of Obesity, investigators from Baylor College of Medicine utilized a high fat diet (HFD)-fed mouse model of obesity and type II diabetes to evaluate the effects of myostatin inhibition using PINTA 745.
The paper is available at the following web location:
http://www.nature.com/ijo/journal/vaop/naam/index.html#05102015
“The data published today further clarify the molecular mechanisms of PINTA 745’s pharmacology. The ongoing phase 2 clinical trial with PINTA 745 includes collection of preliminary data on insulin sensitivity, inflammation, and body composition in patients with End-Stage Renal Disease,” said Christopher Haqq, MD, PhD, Chief Medical Officer of Atara Bio. “We intend to further explore the role of myostatin inhibition in glucose and fat metabolism.”
About PINTA 745
PINTA 745 is a peptibody that binds myostatin and inhibits its corresponding signal transduction, thereby blocking the negative regulation of skeletal muscle growth. Atara Bio is conducting a Phase 2 trial in patients with End Stage Renal Disease (ESRD) who are also suffering from protein energy wasting (PEW) at six US-based sites. PEW refers to a state of muscle wasting, inflammation and malnutrition that increases patients’ risk for infections, cardiovascular disease and other complications. The company believes that patients with PEW may benefit from the muscle building demonstrated in earlier clinical trials and anti-inflammatory properties of PINTA 745 demonstrated in preclinical studies. The clinical trial was designed to provide initial safety and efficacy data in dialysis patients with ESRD.
About Atara Biotherapeutics, Inc.
Atara Biotherapeutics, Inc. is a biopharmaceutical company focused on developing innovative therapies for patients with debilitating diseases. Atara Bio’s programs include molecularly targeted product candidates and T-cell product candidates. Molecularly targeted product candidates include PINTA 745, STM 434 and ATA 842. These product candidates target myostatin and activin, members of the TGF-beta family of proteins, and have demonstrated the potential to have therapeutic benefit in a number of clinical indications. T-cell product candidates include EBV-CTL, CMV-CTL and WT1-CTL.
SOURCE: Atara Biotherapeutics
Post Views: 38
Preclinical Data Published in the International Journal of Obesity
SOUTH SAN FRANCISCO, CA, USA I October 05, 2015 I Atara Biotherapeutics, Inc. (ATRA), a biopharmaceutical company with a focus on developing innovative therapies for patients with debilitating diseases, today announced the publication of preclinical data that provide insight into the pharmacology of its clinical stage anti-myostatin peptibody, PINTA 745.
In the International Journal of Obesity, investigators from Baylor College of Medicine utilized a high fat diet (HFD)-fed mouse model of obesity and type II diabetes to evaluate the effects of myostatin inhibition using PINTA 745.
The paper is available at the following web location:
http://www.nature.com/ijo/journal/vaop/naam/index.html#05102015
“The data published today further clarify the molecular mechanisms of PINTA 745’s pharmacology. The ongoing phase 2 clinical trial with PINTA 745 includes collection of preliminary data on insulin sensitivity, inflammation, and body composition in patients with End-Stage Renal Disease,” said Christopher Haqq, MD, PhD, Chief Medical Officer of Atara Bio. “We intend to further explore the role of myostatin inhibition in glucose and fat metabolism.”
About PINTA 745
PINTA 745 is a peptibody that binds myostatin and inhibits its corresponding signal transduction, thereby blocking the negative regulation of skeletal muscle growth. Atara Bio is conducting a Phase 2 trial in patients with End Stage Renal Disease (ESRD) who are also suffering from protein energy wasting (PEW) at six US-based sites. PEW refers to a state of muscle wasting, inflammation and malnutrition that increases patients’ risk for infections, cardiovascular disease and other complications. The company believes that patients with PEW may benefit from the muscle building demonstrated in earlier clinical trials and anti-inflammatory properties of PINTA 745 demonstrated in preclinical studies. The clinical trial was designed to provide initial safety and efficacy data in dialysis patients with ESRD.
About Atara Biotherapeutics, Inc.
Atara Biotherapeutics, Inc. is a biopharmaceutical company focused on developing innovative therapies for patients with debilitating diseases. Atara Bio’s programs include molecularly targeted product candidates and T-cell product candidates. Molecularly targeted product candidates include PINTA 745, STM 434 and ATA 842. These product candidates target myostatin and activin, members of the TGF-beta family of proteins, and have demonstrated the potential to have therapeutic benefit in a number of clinical indications. T-cell product candidates include EBV-CTL, CMV-CTL and WT1-CTL.
SOURCE: Atara Biotherapeutics
Post Views: 38
