Safety and Efficacy Results Are Expected in Second Half of 2024 Evaluating AX-158, a First in Class Nck Blocker, Shifting the Paradigm of Autoimmune Disease Treatment

AX-158 Has Broad Potential to Treat Many Autoimmune Diseases without Causing Immunosuppression

Autoimmune Diseases Remain a Significant Unmet Medical Need, Affecting Millions of Patients Globally

CAMBRIDGE, MA, USA I February 13, 2024 I Artax Biopharma, Inc., a clinical-stage biotechnology company focused on transforming the treatment of autoimmune diseases, today announces that the first patient has been dosed in the Company’s Phase 2a trial evaluating the safety and biomarker responses of AX-158 in a first proof of mechanism trial in psoriasis. The Company expects these results to be available in the second half of this year.

“We are excited about AX-158’s potential as the first immunomodulator in the Nck blocker class.  Our pre-clinical data supports the potential for AX-158 to realize effective outcomes without the immunosuppression and the side effects associated with existing autoimmune disease therapies,” stated Artax Chief Executive Officer, Rob Armstrong, Ph.D.  “We are eager to see this validation when the results from this psoriasis Phase 2a trial are available later this year.”

Immunomodulation assists the immune system in maintaining healthy control, addressing the underlying driver of autoimmune diseases. As the first in a new class of Nck blockers, AX-158 has the potential to establish a new standard of care in autoimmune disease treatment.  By selectively targeting Nck function, which plays a critical role in immune system function, AX-158 recalibrates the body’s T-cell receptor (TCR) responses.  This recalibration to responses allows the immune system to continue functioning properly and activate only when it recognizes true disease threats – preventing self-activation without causing immune suppression that makes the body susceptible to numerous infections.

“The new Nck blocker class of agents, AX-158, has the potential to change how we treat autoimmune disease through targeting and tempering TCR responses so the body only, and properly, reacts against strong pathogens,” commented James G. Krueger, M.D., Ph.D., Head of the Laboratory for Investigative Dermatology at The Rockefeller University and Artax Scientific Advisory Board member. “I am excited to see how this new mechanism of action translates into biomarker changes and patient responses, where to date only targeted immunosuppression has been applied.”

About Autoimmune Disease and Psoriasis 
Psoriasis is a common, immune-mediated disease that affects 125 million people globally. In the US 3.0% of the adult population, or more than 7.5 million adults, are affected. Psoriasis patients may exhibit visible signs of inflammation anywhere on the body as raised plaques and scales on the skin. Plaques may appear as few small patches or can affect large areas. It is possible to have psoriasis plaques and scales on more than one location on the body at a time. Treating psoriasis can help improve symptoms as well as lower the risk of developing other health conditions such as psoriatic arthritis, heart disease, obesity, diabetes, and depression.

About Artax Biopharma
Artax Biopharma is a clinical-stage biotechnology company transforming the treatment of T Cell-driven autoimmune diseases. Artax’s first-in-class oral small molecules aim to deliver immune system modulation without immunosuppression, potentially unlocking new treatment options as both monotherapy and in combination with other treatments. The lead program AX-158 will deliver Phase 2a Proof of Concept data in psoriasis later in 2024.

We believe there is significant potential for its approach to revolutionize treatment of T Cell-driven diseases. Immunomodulation maintains healthy control of the immune system and addresses the underlying source of T Cell-driven diseases. Central to a well-functioning immune system is the T Cell Receptor (TCR). When TCR signaling becomes dysregulated, it causes T Cell-driven conditions, including autoimmune diseases, and induced T Cell pathologies where medical treatments result in immune reactions (such as stem cell transplants resulting in acute graft-versus-host-disease or immuno-oncology treatments resulting in immune related-adverse events). We believe the immunomodulation mechanism offered by our investigational agents holds broad potential to revolutionize how these T Cell-driven autoimmune diseases are addressed, while not impairing the ability of a patient’s immune system to function properly.

Artax Biopharma is based in the Boston area and raised Series A & B from Advent Life Sciences, Sound Bioventures, and Columbus Venture Partners. For more info, see or follow us on LinkedIn.

For Phase 2a study inquiries, please contact:

SOURCE: Artax Biopharma