PASADENA, CA, USA I October 25, 2021 I Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) today announced that it has filed an application for clearance to begin a Phase 1/2a clinical trial of ARO-C3, the company’s investigational RNA interference (RNAi) therapeutic being developed as a treatment for patients with various complement mediated diseases. Arrowhead will host a key opinion leader (KOL) webinar on October 26, 2021, at 3:00 p.m. ET to discuss ARO-C3 and the company’s development plans.

Chris Anzalone, Ph.D., president and chief executive officer of Arrowhead, said: “ARO-C3 utilizes Arrowhead’s proprietary TRiM™ platform to silence the hepatic production of complement C3. This will be our tenth TRiM™-enabled clinical program and the eighth targeting a liver expressed protein. In all of our liver-targeted programs to date, we have seen consistent and efficient translation of preclinical in vivo results to human clinical results, so we have a high degree of confidence in investigational ARO-C3. In addition, we view ARO-C3 as having the potential to address multiple serious complement-mediated or complement-associated diseases with unmet need in the renal and hematology space. We look forward to discussing the program in more detail on October 26, 2021 when we host a webinar, during which key opinion leaders will describe some of the diseases that may potentially be addressed by ARO-C3. These include IgA nephropathy, C3 glomerulopathy, and paroxysmal nocturnal hemoglobinuria.”

An application for approval of the clinical trial is being submitted to a local Ethics Committee and to the New Zealand Medicines and Medical Devices Safety Authority for review by the Standing Committee on Therapeutic Trials. Pending clearance, Arrowhead intends to proceed with AROC3-1001, a Phase 1/2a dose-escalating study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ARO-C3 in up to 24 adult healthy volunteers and in up to 24 adult patients with paroxysmal nocturnal hemoglobinuria and up to 14 adult patients with complement-mediated renal disease.

The webinar will feature presentations by KOLs Richard J. Glassock, MD, MACP, FRCP, FASN (David Geffen School of Medicine at UCLA), and Peter Browett, BMedSci, MBChB, FRACP, FRCPA (University of Auckland School of Medicine). They will discuss the current treatment landscape and unmet medical need in treating patients with complement mediated renal and hematological diseases. Arrowhead’s management team will discuss the biology of the target, preclinical data generated to date, and clinical plans for ARO-C3. ARO-C3 is designed to reduce production of complement component 3 (C3) as a potential therapy for various complement mediated diseases.

The webinar may be accessed on the Events and Presentations page under the Investors section of the Arrowhead website on October 26, and a replay will be made available following the conclusion of the webinar.

About Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

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SOURCE: Arrowhead Pharmaceuticals