SALT LAKE CITY, UT, USA I June 28, 2017 I Arrien Pharmaceuticals (Arrien) announced today that it has completed a worldwide license agreement with a U.S.-based pharmaceutical company for their Phase 1 clinical agent, ARN-6039, which will be developed for the potential treatment of moderate to severe psoriasis and potentially other autoimmune disorders. The license agreement covers the clinical agent ARN-6039 and Arrien’s series of ROR-γt targeting compounds. The financial considerations of this license agreement are undisclosed, but include an upfront license fee, development milestones, sales milestones and royalties on net sales. Prior to licensing, Arrien completed a single U.S. center Phase I clinical trial and established the safety, tolerability and pharmacokinetics of single ascending doses of ARN-6039 in healthy adult subjects. The partnership of ARN-6039 at the Phase 1 stage of development is an important milestone for Arrien, validating Arrien’s proprietary small molecule fragment-based discovery platform (FIELDS).

ARN-6039 is an inverse agonist of ROR-γt, a transcription factor that regulates TH17 and the production of IL-17 and IL-17A, pro-inflammatory cytokines critical to the immunopathology of autoimmune diseases, including psoriasis. Inhibition of ROR-γt has been shown both pre-clinically and clinically to have efficacy in the treatment of multiple autoimmune disorders. ARN-6039 was discovered through Arrien’s proprietary FIELDS drug discovery technology platform.

About Psoriasis ARN-6039

Psoriasis, is a common chronic autoimmune disorder of the skin affecting nearly 3% of the world’s population, or approximately 125 million people worldwide. Increased activity of TH17 (T helper 17) cells, and the associated excess production of pro-inflammatory cytokines, including IL-17 and IL-17A, are critical elements in the pathophysiology of psoriasis. ROR-γt, is a nuclear hormone receptor that is essential for the formation and function of TH17 cells. These pro-inflammatory cytokines cause cells to rapidly multiply and build up on the skin’s surface, resulting in red scaly patches, causing pain and pruritis.

Arrien Pharmaceuticals discovered and advanced the development of ARN-6039, an inverse-agonist targeting ROR-γt, a key transcription factor and the master regulator of human TH17 (T helper 17) cells. ROR-γt controls cellular differentiation, function, and IL-17 release by TH17 cells and may help mediate the immunopathology of a broad range of autoimmune diseases, including psoriasis. Arrien believes that ARN-6039 is one of the most advanced agents in development targeting ROR-γt.

About Arrien Pharmaceuticals

Arrien Pharmaceuticals is a targeted therapeutics drug discovery and development company. Arrien applies its proprietary fragment-based FIELDS drug discovery technology to target kinase signaling and nuclear receptor pathways, which are critical pathways in inflammation, autoimmune diseases, cancer, and neurodegenerative diseases. Arrien has developed a pipeline of novel pre-clinical programs for future potential treatment of Multiple Sclerosis (MS), Psoriasis, Cancer, Rheumatoid Arthritis (RA), and Parkinson’s Disease (PD).

For further information on Arrien Pharmaceuticals, please visit the company’s website

SOURCE: Arrien Pharmaceuticals