• Preclinical Data Supports Advancement of ALLO-715 into Phase 1 in Multiple Myeloma
  • ALLO-715 Investigational New Drug Application and Initiation of a Phase 1 Trial Planned for 2019

SOUTH SAN FRANCISCO, CA, USA I December 03, 2018 I Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T™) therapies for cancer, today announced results of a preclinical study of ALLO-715, an AlloCAR T therapy targeting B-cell maturation antigen (BCMA) in development by Allogene. The findings demonstrate the potential of ALLO-715 as a novel AlloCAR T therapy for multiple myeloma and other BCMA-positive malignancies. The data were presented today by Cesar Sommer, Ph.D., Principal Scientist at Allogene, in an oral session at the 60th American Society of Hematology (ASH) Annual Meeting & Exposition in San Diego.

“Based on these promising preclinical data, we plan to submit an Investigational New Drug (IND) application for ALLO-715 and initiate a Phase 1 clinical trial in 2019 in relapsed or refractory multiple myeloma,” said David Chang, M.D., Ph.D., President, Chief Executive Officer and Co-Founder of Allogene. “AlloCAR T therapies have the potential to expand patient access to cell therapies for patients who may benefit due to the off-the-shelf and on-demand characteristics of AlloCAR T.”

The preclinical study evaluated the specificity of ALLO-715 to human BCMA and its anti-tumor efficacy in vitro and in animal models. ALLO-715 displayed potent cytotoxic activity against multiple myeloma cell lines. In animal models, ALLO-715 was highly efficacious at a single dose, demonstrating potent anti-tumor activity.

ALLO-715 utilizes the TALEN® gene-editing technology pioneered and owned by Cellectis. It was progressed under a joint research collaboration with the company and is directed at a target that was licensed exclusively from Cellectis. Allogene holds the global development and commercial rights for this investigational candidate.

About Allogene Therapeutics
Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) therapies for cancer. Led by a world-class management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell therapy candidates with the goal of delivering readily available cell therapy faster, more reliably and at greater scale to more patients.

AlloCAR T™ cell therapies are engineered from cells of healthy donors, which is intended to allow for creation of inventory for on demand use in patients. This approach is designed to eliminate the need to create personalized therapy from a patient’s own cells, simplify manufacturing, and reduce the time patients must wait for CAR T cell treatment. The Allogene portfolio includes rights to 16 pre-clinical CAR T cell therapy assets and UCART19, an AlloCAR T therapy candidate currently in Phase 1 sponsored by Servier for the treatment of relapsed/refractory acute lymphoblastic leukemia (ALL). For more information, please visit www.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.

SOURCE: Allogene Therapeutics