LEXINGTON, MA, USA I July 18, 2017 I Aldeyra Therapeutics, Inc. (NASDAQ: ALDX) (Aldeyra), a clinical-stage biotechnology company devoted to treating inflammation, inborn errors of metabolism, and other diseases related to aldehydes, today announced that the last patient has completed dosing in Aldeyra’s single-center, double-blind, randomized Phase 2a clinical trial of ADX-102 in Dry Eye Disease (DED).
“Current therapy for Dry Eye Disease is generally regarded as inadequate,” commented Todd C. Brady, M.D., Ph.D., President and CEO of Aldeyra. “By diminishing ocular inflammation and protecting lipids required for ocular surface lubrication, ADX-102 represents a novel, dual-acting potential therapeutic approach to a common disease, estimated to affect 10% or more of the worldwide population. We look forward to providing data from the trial later this quarter.”
ADX-102 and other product candidates generated from Aldeyra’s aldehyde trap platform sequester and facilitate the degradation of aldehydes, a class of endogenously generated pro-inflammatory mediators that are elevated in DED patients. The Phase 2a clinical trial tested three formulations of topical ocular ADX-102 (0.5% ADX-102 ophthalmic solution, 0.1% ADX-102 ophthalmic solution, and 0.5% ADX-102 ophthalmic lipid solution) over 28 days of dosing. The primary purpose of the study was to assess the safety and tolerability of ADX-102 in forty-five patients with a reported history of DED. Endpoints included standard signs and symptoms characteristic of DED.
Topical ocular ADX-102 is also in late-stage clinical development for the treatment of allergic conjunctivitis and noninfectious anterior uveitis, two other forms of ocular inflammation.
About Aldeyra Therapeutics
Aldeyra Therapeutics, Inc. is a biotechnology company devoted to improving lives by inventing, developing and commercializing products that treat diseases thought to be related to endogenous aldehydes, a naturally occurring class of pro-inflammatory and toxic molecules. Aldeyra’s lead product candidate, ADX-102, is an aldehyde trap in development for ocular inflammation, as well as for Sjögren-Larsson Syndrome and Succinic Semi-Aldehyde Dehydrogenase Deficiency, two inborn errors of aldehyde metabolism. Aldeyra’s product candidates have not been approved for sale in the U.S. or elsewhere.
About Dry Eye Disease
Dry Eye Disease is a common inflammatory disease characterized by insufficient moisture and lubrication in the anterior surface of the eye. Symptoms may include ocular irritation, burning or stinging, and, in severe cases, decreased vision. In patients with Dry Eye Disease, aldehydes may contribute to ocular inflammation as well as the impairment of lipids (fats) that lubricate the surface of the eye.
SOURCE: Aldeyra Therapeutics
Post Views: 91
LEXINGTON, MA, USA I July 18, 2017 I Aldeyra Therapeutics, Inc. (NASDAQ: ALDX) (Aldeyra), a clinical-stage biotechnology company devoted to treating inflammation, inborn errors of metabolism, and other diseases related to aldehydes, today announced that the last patient has completed dosing in Aldeyra’s single-center, double-blind, randomized Phase 2a clinical trial of ADX-102 in Dry Eye Disease (DED).
“Current therapy for Dry Eye Disease is generally regarded as inadequate,” commented Todd C. Brady, M.D., Ph.D., President and CEO of Aldeyra. “By diminishing ocular inflammation and protecting lipids required for ocular surface lubrication, ADX-102 represents a novel, dual-acting potential therapeutic approach to a common disease, estimated to affect 10% or more of the worldwide population. We look forward to providing data from the trial later this quarter.”
ADX-102 and other product candidates generated from Aldeyra’s aldehyde trap platform sequester and facilitate the degradation of aldehydes, a class of endogenously generated pro-inflammatory mediators that are elevated in DED patients. The Phase 2a clinical trial tested three formulations of topical ocular ADX-102 (0.5% ADX-102 ophthalmic solution, 0.1% ADX-102 ophthalmic solution, and 0.5% ADX-102 ophthalmic lipid solution) over 28 days of dosing. The primary purpose of the study was to assess the safety and tolerability of ADX-102 in forty-five patients with a reported history of DED. Endpoints included standard signs and symptoms characteristic of DED.
Topical ocular ADX-102 is also in late-stage clinical development for the treatment of allergic conjunctivitis and noninfectious anterior uveitis, two other forms of ocular inflammation.
About Aldeyra Therapeutics
Aldeyra Therapeutics, Inc. is a biotechnology company devoted to improving lives by inventing, developing and commercializing products that treat diseases thought to be related to endogenous aldehydes, a naturally occurring class of pro-inflammatory and toxic molecules. Aldeyra’s lead product candidate, ADX-102, is an aldehyde trap in development for ocular inflammation, as well as for Sjögren-Larsson Syndrome and Succinic Semi-Aldehyde Dehydrogenase Deficiency, two inborn errors of aldehyde metabolism. Aldeyra’s product candidates have not been approved for sale in the U.S. or elsewhere.
About Dry Eye Disease
Dry Eye Disease is a common inflammatory disease characterized by insufficient moisture and lubrication in the anterior surface of the eye. Symptoms may include ocular irritation, burning or stinging, and, in severe cases, decreased vision. In patients with Dry Eye Disease, aldehydes may contribute to ocular inflammation as well as the impairment of lipids (fats) that lubricate the surface of the eye.
SOURCE: Aldeyra Therapeutics
Post Views: 91
