MENLO PARK, CA, USA I October 23, 2017 I CohBar, Inc. (OTCQX:CWBR) (TSXV:COB.U), an innovative biotechnology company focused on developing mitochondria based therapeutics (MBTs) to treat age-related diseases, today announced the presentation of preclinical data on its lead CB4209/CB4211 program for NASH at the 2017 American Association for the Study of Liver Diseases (AASLD) Liver Meeting, taking place October 20-24, 2017 in Washington DC. NASH (non-alcoholic steatohepatitis) affects as many as 12% of adults in the US and there is currently no approved treatment for the disease.
The new data were presented in a poster entitled: “CB4209 and CB4211 Reduce the NAFLD Activity Score in the STAM Model of NASH, Reduce Triglyceride Levels, and Induce Selective Fat Mass Loss in DIO Mice.”
In the poster, CohBar scientists and their collaborators provided in vitro evidence that CB4209 and CB4211 inhibit adipocyte lipolysis, a process that is foundational in the development of liver steatosis. These data corroborate previous in vivo evidence of anti-steatotic effects of the peptides on livers of mice on a high fat diet, where a corresponding reduction in circulating fat and biomarkers of liver damage was observed. Reduction of excess body weight was confined to obese animals and was not seen in healthy animals even at much higher doses. The in vivo effects on steatosis and body weight in obese mice were further shown to be synergistic with the activity of concomitant liraglutide, a GLP-1 agonist approved for the treatment of type 2 diabetes and obesity. In the widely-studied STAM® mouse model of NASH, significant reductions in the NAFLD activity score (NAS) were seen for CB4209 (24% reduction) and CB4211 (33% reduction) (P<0.01). Positive effects of these peptides were detected on all three components of the NAS score (steatosis, inflammation, and hepatocyte ballooning). Levels of liver triglycerides and circulating ALT, a marker of liver damage, in the STAM mice were significantly improved by treatment with these peptides.
“The preclinical data for CB4209 and CB4211 demonstrate the therapeutic potential of novel analogs derived from peptides encoded in the mitochondrial genome,” said Kenneth C. Cundy, Ph.D., CohBar’s Chief Scientific Officer. “The peptides have a regulatory effect on the secretion of free fatty acids from fat cells, a process that is overactive in obese subjects and a potential contributing factor in many of the pathological consequences of metabolic dysregulation. We believe our peptides affect a foundational event in the etiology of NASH and potentially other metabolic diseases. CB4209/CB4211 may also offer a complementary approach to other mechanisms of action currently being explored in the emerging field of NASH therapeutics. We look forward to further testing the potential of our MBTs in clinical studies.”
“Lipotoxicity is a key mechanism in a number of metabolic diseases and is thought to be responsible for the progression of NAFLD to NASH,” said CohBar advisor, Dr. Rohit Loomba, MD, Professor of Medicine in the Division of Gastroenterology and Adjunct Professor in the Division of Epidemiology at UC San Diego and Director, NAFLD Research Center. “A drug that addresses the underlying process of lipid secretion from visceral fat cells could potentially provide a new option for treating this major liver disease.”
About CohBar’s Lead Program
CohBar’s lead preclinical development program is based on MOTS-c, a mitochondrial-derived peptide discovered in 2012 by the Company’s founders and their academic collaborators, whose research has shown that MOTS-c plays a significant role in the regulation of metabolism. The Company has developed novel, improved analogs of the MOTS-c peptide, CB4209 and CB4211, which have demonstrated significant therapeutic potential in preclinical models of obesity and nonalcoholic steatohepatitis (NASH).
About CohBar
CohBar (OTCQX:CWBR) (TSXV:COB.U) is an innovative biotechnology company focused on the research and development of mitochondria based therapeutics (MBTs), an emerging class of drugs for the treatment of age-related diseases. MBTs originate from the discovery by CohBar’s founders of a novel group of peptides within the mitochondrial genome which regulate metabolism and cell death, and whose biological activity declines with age. CohBar’s efforts focus on the development of these mitochondrial-derived peptides (MDPs) into clinically relevant MBTs that offer the potential to address a broad range of age-related diseases, including obesity, fatty liver disease (NASH), type 2 diabetes, cancer, cardiovascular and neurodegenerative diseases. To date, the Company and its founders have discovered more than 100 MDPs.
SOURCE: CohBar
Post Views: 70
MENLO PARK, CA, USA I October 23, 2017 I CohBar, Inc. (OTCQX:CWBR) (TSXV:COB.U), an innovative biotechnology company focused on developing mitochondria based therapeutics (MBTs) to treat age-related diseases, today announced the presentation of preclinical data on its lead CB4209/CB4211 program for NASH at the 2017 American Association for the Study of Liver Diseases (AASLD) Liver Meeting, taking place October 20-24, 2017 in Washington DC. NASH (non-alcoholic steatohepatitis) affects as many as 12% of adults in the US and there is currently no approved treatment for the disease.
The new data were presented in a poster entitled: “CB4209 and CB4211 Reduce the NAFLD Activity Score in the STAM Model of NASH, Reduce Triglyceride Levels, and Induce Selective Fat Mass Loss in DIO Mice.”
In the poster, CohBar scientists and their collaborators provided in vitro evidence that CB4209 and CB4211 inhibit adipocyte lipolysis, a process that is foundational in the development of liver steatosis. These data corroborate previous in vivo evidence of anti-steatotic effects of the peptides on livers of mice on a high fat diet, where a corresponding reduction in circulating fat and biomarkers of liver damage was observed. Reduction of excess body weight was confined to obese animals and was not seen in healthy animals even at much higher doses. The in vivo effects on steatosis and body weight in obese mice were further shown to be synergistic with the activity of concomitant liraglutide, a GLP-1 agonist approved for the treatment of type 2 diabetes and obesity. In the widely-studied STAM® mouse model of NASH, significant reductions in the NAFLD activity score (NAS) were seen for CB4209 (24% reduction) and CB4211 (33% reduction) (P<0.01). Positive effects of these peptides were detected on all three components of the NAS score (steatosis, inflammation, and hepatocyte ballooning). Levels of liver triglycerides and circulating ALT, a marker of liver damage, in the STAM mice were significantly improved by treatment with these peptides.
“The preclinical data for CB4209 and CB4211 demonstrate the therapeutic potential of novel analogs derived from peptides encoded in the mitochondrial genome,” said Kenneth C. Cundy, Ph.D., CohBar’s Chief Scientific Officer. “The peptides have a regulatory effect on the secretion of free fatty acids from fat cells, a process that is overactive in obese subjects and a potential contributing factor in many of the pathological consequences of metabolic dysregulation. We believe our peptides affect a foundational event in the etiology of NASH and potentially other metabolic diseases. CB4209/CB4211 may also offer a complementary approach to other mechanisms of action currently being explored in the emerging field of NASH therapeutics. We look forward to further testing the potential of our MBTs in clinical studies.”
“Lipotoxicity is a key mechanism in a number of metabolic diseases and is thought to be responsible for the progression of NAFLD to NASH,” said CohBar advisor, Dr. Rohit Loomba, MD, Professor of Medicine in the Division of Gastroenterology and Adjunct Professor in the Division of Epidemiology at UC San Diego and Director, NAFLD Research Center. “A drug that addresses the underlying process of lipid secretion from visceral fat cells could potentially provide a new option for treating this major liver disease.”
About CohBar’s Lead Program
CohBar’s lead preclinical development program is based on MOTS-c, a mitochondrial-derived peptide discovered in 2012 by the Company’s founders and their academic collaborators, whose research has shown that MOTS-c plays a significant role in the regulation of metabolism. The Company has developed novel, improved analogs of the MOTS-c peptide, CB4209 and CB4211, which have demonstrated significant therapeutic potential in preclinical models of obesity and nonalcoholic steatohepatitis (NASH).
About CohBar
CohBar (OTCQX:CWBR) (TSXV:COB.U) is an innovative biotechnology company focused on the research and development of mitochondria based therapeutics (MBTs), an emerging class of drugs for the treatment of age-related diseases. MBTs originate from the discovery by CohBar’s founders of a novel group of peptides within the mitochondrial genome which regulate metabolism and cell death, and whose biological activity declines with age. CohBar’s efforts focus on the development of these mitochondrial-derived peptides (MDPs) into clinically relevant MBTs that offer the potential to address a broad range of age-related diseases, including obesity, fatty liver disease (NASH), type 2 diabetes, cancer, cardiovascular and neurodegenerative diseases. To date, the Company and its founders have discovered more than 100 MDPs.
SOURCE: CohBar
Post Views: 70
