SAN DIEGO, CA, USA I October 2, 2017 I Ignyta, Inc. (Nasdaq: RXDX), a biotechnology company focused on precision medicine in oncology, today announced new preclinical data for RXDX-106 – a novel immunomodulatory agent with potent anti-tumor activity, alone and in combination with checkpoint inhibitors, that appears to restore and enhance overall immune function by reversing immunosuppression of innate immune cells in the tumor microenvironment (TME) through TYRO3, AXL, and MER (TAM) receptor tyrosine kinase (RTK) inhibition. The data were presented in a poster session (abstract number A37) at the American Association for Cancer Research (AACR) Special Conference on Tumor Immunology and Immunotherapy in Boston, Massachusetts.
“We continue to be excited by the preclinical profile of RXDX-106 and its potential to elicit and potentiate an immune response to cancer, both as a single agent and combined with checkpoint inhibitors,” said Jonathan Lim, M.D., chairman and CEO of Ignyta. “TAM receptors are novel immuno-oncologic RTK targets for precision medicine therapies such as RXDX-106, which we are eager to bring into the clinic as soon as possible to potentially help patients in their fight against cancer.”
In the study, researchers demonstrated immune-mediated, single-agent anti-tumor activity of RXDX-106 in multiple tumor models. The anti-tumor effect was further enhanced by combination therapy with immune checkpoint inhibitors, potentially by reversing immunosuppression of innate immunity in the TME. The data also suggest that RXDX-106 has a novel mechanism of enhancing overall immune function by activating both innate and adaptive immunity, as observed by treatment-mediated changes in relevant cytokine levels and immune cell biomarkers, and regulating cross-talk between immune and cancer cells. These promising early findings support further development of RXDX-106 to potentially treat a wide variety of cancers.
About Ignyta, Inc.
Blazing a New Future for Patients with CancerTM
At Ignyta, we work tirelessly on behalf of patients with cancer to offer potentially life-saving, precisely targeted therapeutics (Rx) guided by diagnostic (Dx) tests. Our integrated Rx/Dx strategy allows us to enter uncharted territory, illuminating the molecular drivers of cancer and quickly advancing treatments to address them. This approach embraces even those patients with rare cancers, who have the highest unmet need and who may otherwise not have access to effective treatment options. With our pipeline of potentially first-in-class or best-in-class precision medicines, we are pursuing the ultimate goal of not just shrinking tumors, but eradicating cancer relapse and recurrence in precisely defined patient populations.
SOURCE: Ignyta
Post Views: 89
SAN DIEGO, CA, USA I October 2, 2017 I Ignyta, Inc. (Nasdaq: RXDX), a biotechnology company focused on precision medicine in oncology, today announced new preclinical data for RXDX-106 – a novel immunomodulatory agent with potent anti-tumor activity, alone and in combination with checkpoint inhibitors, that appears to restore and enhance overall immune function by reversing immunosuppression of innate immune cells in the tumor microenvironment (TME) through TYRO3, AXL, and MER (TAM) receptor tyrosine kinase (RTK) inhibition. The data were presented in a poster session (abstract number A37) at the American Association for Cancer Research (AACR) Special Conference on Tumor Immunology and Immunotherapy in Boston, Massachusetts.
“We continue to be excited by the preclinical profile of RXDX-106 and its potential to elicit and potentiate an immune response to cancer, both as a single agent and combined with checkpoint inhibitors,” said Jonathan Lim, M.D., chairman and CEO of Ignyta. “TAM receptors are novel immuno-oncologic RTK targets for precision medicine therapies such as RXDX-106, which we are eager to bring into the clinic as soon as possible to potentially help patients in their fight against cancer.”
In the study, researchers demonstrated immune-mediated, single-agent anti-tumor activity of RXDX-106 in multiple tumor models. The anti-tumor effect was further enhanced by combination therapy with immune checkpoint inhibitors, potentially by reversing immunosuppression of innate immunity in the TME. The data also suggest that RXDX-106 has a novel mechanism of enhancing overall immune function by activating both innate and adaptive immunity, as observed by treatment-mediated changes in relevant cytokine levels and immune cell biomarkers, and regulating cross-talk between immune and cancer cells. These promising early findings support further development of RXDX-106 to potentially treat a wide variety of cancers.
About Ignyta, Inc.
Blazing a New Future for Patients with CancerTM
At Ignyta, we work tirelessly on behalf of patients with cancer to offer potentially life-saving, precisely targeted therapeutics (Rx) guided by diagnostic (Dx) tests. Our integrated Rx/Dx strategy allows us to enter uncharted territory, illuminating the molecular drivers of cancer and quickly advancing treatments to address them. This approach embraces even those patients with rare cancers, who have the highest unmet need and who may otherwise not have access to effective treatment options. With our pipeline of potentially first-in-class or best-in-class precision medicines, we are pursuing the ultimate goal of not just shrinking tumors, but eradicating cancer relapse and recurrence in precisely defined patient populations.
SOURCE: Ignyta
Post Views: 89
