BIND Therapeutics and AstraZeneca Publish Preclinical Data Illustrating ACCURINS® Ability to Utilize Proprietary Hydrophobic Ion Pairing to Increase Biodistribution to Tumor Sites of Molecularly Targeted Agents
CAMBRIDGE, MA, USA I February 10, 2016 I BIND Therapeutics, Inc. (NASDAQ: BIND), a clinical-stage nanomedicine company developing innovative therapeutics called ACCURINS®, today announced the publication of data highlighting the ability of ACCURIN polymeric nanoparticle technology to utilize hydrophobic ion pairing and improve the therapeutic index of a molecularly targeted anti-cancer drug. Previous efforts with nanotechnology have focused almost exclusively on encapsulating chemotherapy payloads; the publication describes one of the first efforts to apply nanotechnology to a molecular targeted agent. Results highlight the potential for ACCURINS® to control release kinetics and provide increased concentration of an aurora B kinase inhibitor, AZD2811, at tumor sites resulting in prolonged pharmacodynamic effects, superior tumor growth inhibition and a reduction in on-target but off-tissue toxicity. These data were published in the February 10, 2016 issue of Science Translational Medicine.
“These data demonstrate the potential to extend the benefits of our ACCURIN platform beyond chemotherapy payloads to kinase inhibitors, which are a rapidly growing component of the armamentarium against cancer,” said Jonathan Yingling, Ph.D., chief scientific officer at BIND Therapeutics. “The data in this publication illustrate that ACCURINS® are able to entrap and control the release rate of payloads with wide ranging physicochemical properties, including molecules with ionizable functional groups, which enables our platform to generate more novel and innovative medicines beyond targeted chemotherapies. There are multiple oncogenic pathways that have proven difficult to target with conventional approaches and that we believe the targeted and modular nature of ACCURIN nanomedicines are well suited to address.”
In the paper entitled, “Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo,” researchers demonstrated the accumulation and retention of a specific AZD2811 nanoparticle formulation in tumors, resulting in an extended reduction of tumor phosphorylated histone H3 levels in vivo for up to 96 hours following a single administration with minimal impact on bone marrow pathology. This formulation also demonstrated continuous drug release for more than one week in vitro, and displayed lower toxicity and increased efficacy in multiple tumor models at half the dose intensity of a water-soluble prodrug of AZD2811. These preclinical studies using ion pairing agents with AZD2811 and ACCURIN technology suggested improved tolerability as well as less frequent dosing.
“Data from this paper support the recent initiation of the phase 1 trial with AZD2811, the first nanoparticle that encapsulates a molecularly targeted drug to enter the clinic,” said Andrew Hirsch, BIND’s president and chief executive officer. “The novel patented hydrophobic ion pairing approach that we developed partially through our collaboration with AstraZeneca demonstrates an important benefit of our collaboration strategy. This new approach has significantly expanded the number of payloads that are compatible with our ACCURIN platform and is enabling us to explore new applications of our ACCURIN technology such as extra-hepatic delivery of oligonucleotide-based therapeutics, targeted antibiotics, and novel immuno-oncology approaches.”
About BIND Therapeutics
BIND Therapeutics is a clinical-stage nanomedicine company developing a pipeline of ACCURINS®, its novel targeted therapeutics designed to increase the concentration and duration of therapeutic payloads at disease sites while reducing exposure to healthy tissue. BIND is leveraging its Medicinal Nanoengineering® platform to develop a pipeline of ACCURINS® targeting hematological and solid tumors and has a number of strategic collaborations with biopharmaceutical companies to develop ACCURINS® in areas of high unmet need. BIND’s lead drug candidate, BIND-014, is a prostate-specific membrane antigen (PSMA) -targeted ACCURIN that contains docetaxel, a clinically-validated and widely-used cancer chemotherapy drug. BIND is currently evaluating BIND-014 in the phase 2 iNSITE 1 trial for non-small cell lung cancer, or NSCLC, with squamous histology. In addition, BIND is enrolling patients in the iNSITE 2 clinical trial with BIND-014 for advanced cancers of the cervix and head and neck. BIND is advancing BIND-510, its second PSMA-targeted ACCURIN drug candidate containing vincristine through important preclinical gating studies to potentially position it for an Investigational New Drug (IND) application filing with the U.S. Food and Drug Administration. BIND is also developing ACCURINS® designed to inhibit PLK1 and KSP, both of which BIND believes are promising anti-mitotic targets that have been limited in the clinic due to systemic toxicity at or below their therapeutic doses.
BIND has announced ongoing collaborations with Pfizer Inc., AstraZeneca AB, F. Hoffmann-La Roche Ltd., Merck & Co., or Merck (known as Merck Sharp & Dohme outside the United States and Canada) and Macrophage Therapeutics (a subsidiary of Navidea Biopharmaceuticals) to develop ACCURINS® based on their proprietary therapeutic payloads and/or targeting ligands. BIND’s collaboration with AstraZeneca has resulted in the Aurora B Kinase inhibitor ACCURIN AZD2811, which became the second ACCURIN candidate to enter clinical development. BIND’s collaboration with Pfizer has resulted in the selection of an ACCURIN candidate that is entering IND-enabling studies.
SOURCE: Bind Therapeutics
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BIND Therapeutics and AstraZeneca Publish Preclinical Data Illustrating ACCURINS® Ability to Utilize Proprietary Hydrophobic Ion Pairing to Increase Biodistribution to Tumor Sites of Molecularly Targeted Agents
CAMBRIDGE, MA, USA I February 10, 2016 I BIND Therapeutics, Inc. (NASDAQ: BIND), a clinical-stage nanomedicine company developing innovative therapeutics called ACCURINS®, today announced the publication of data highlighting the ability of ACCURIN polymeric nanoparticle technology to utilize hydrophobic ion pairing and improve the therapeutic index of a molecularly targeted anti-cancer drug. Previous efforts with nanotechnology have focused almost exclusively on encapsulating chemotherapy payloads; the publication describes one of the first efforts to apply nanotechnology to a molecular targeted agent. Results highlight the potential for ACCURINS® to control release kinetics and provide increased concentration of an aurora B kinase inhibitor, AZD2811, at tumor sites resulting in prolonged pharmacodynamic effects, superior tumor growth inhibition and a reduction in on-target but off-tissue toxicity. These data were published in the February 10, 2016 issue of Science Translational Medicine.
“These data demonstrate the potential to extend the benefits of our ACCURIN platform beyond chemotherapy payloads to kinase inhibitors, which are a rapidly growing component of the armamentarium against cancer,” said Jonathan Yingling, Ph.D., chief scientific officer at BIND Therapeutics. “The data in this publication illustrate that ACCURINS® are able to entrap and control the release rate of payloads with wide ranging physicochemical properties, including molecules with ionizable functional groups, which enables our platform to generate more novel and innovative medicines beyond targeted chemotherapies. There are multiple oncogenic pathways that have proven difficult to target with conventional approaches and that we believe the targeted and modular nature of ACCURIN nanomedicines are well suited to address.”
In the paper entitled, “Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo,” researchers demonstrated the accumulation and retention of a specific AZD2811 nanoparticle formulation in tumors, resulting in an extended reduction of tumor phosphorylated histone H3 levels in vivo for up to 96 hours following a single administration with minimal impact on bone marrow pathology. This formulation also demonstrated continuous drug release for more than one week in vitro, and displayed lower toxicity and increased efficacy in multiple tumor models at half the dose intensity of a water-soluble prodrug of AZD2811. These preclinical studies using ion pairing agents with AZD2811 and ACCURIN technology suggested improved tolerability as well as less frequent dosing.
“Data from this paper support the recent initiation of the phase 1 trial with AZD2811, the first nanoparticle that encapsulates a molecularly targeted drug to enter the clinic,” said Andrew Hirsch, BIND’s president and chief executive officer. “The novel patented hydrophobic ion pairing approach that we developed partially through our collaboration with AstraZeneca demonstrates an important benefit of our collaboration strategy. This new approach has significantly expanded the number of payloads that are compatible with our ACCURIN platform and is enabling us to explore new applications of our ACCURIN technology such as extra-hepatic delivery of oligonucleotide-based therapeutics, targeted antibiotics, and novel immuno-oncology approaches.”
About BIND Therapeutics
BIND Therapeutics is a clinical-stage nanomedicine company developing a pipeline of ACCURINS®, its novel targeted therapeutics designed to increase the concentration and duration of therapeutic payloads at disease sites while reducing exposure to healthy tissue. BIND is leveraging its Medicinal Nanoengineering® platform to develop a pipeline of ACCURINS® targeting hematological and solid tumors and has a number of strategic collaborations with biopharmaceutical companies to develop ACCURINS® in areas of high unmet need. BIND’s lead drug candidate, BIND-014, is a prostate-specific membrane antigen (PSMA) -targeted ACCURIN that contains docetaxel, a clinically-validated and widely-used cancer chemotherapy drug. BIND is currently evaluating BIND-014 in the phase 2 iNSITE 1 trial for non-small cell lung cancer, or NSCLC, with squamous histology. In addition, BIND is enrolling patients in the iNSITE 2 clinical trial with BIND-014 for advanced cancers of the cervix and head and neck. BIND is advancing BIND-510, its second PSMA-targeted ACCURIN drug candidate containing vincristine through important preclinical gating studies to potentially position it for an Investigational New Drug (IND) application filing with the U.S. Food and Drug Administration. BIND is also developing ACCURINS® designed to inhibit PLK1 and KSP, both of which BIND believes are promising anti-mitotic targets that have been limited in the clinic due to systemic toxicity at or below their therapeutic doses.
BIND has announced ongoing collaborations with Pfizer Inc., AstraZeneca AB, F. Hoffmann-La Roche Ltd., Merck & Co., or Merck (known as Merck Sharp & Dohme outside the United States and Canada) and Macrophage Therapeutics (a subsidiary of Navidea Biopharmaceuticals) to develop ACCURINS® based on their proprietary therapeutic payloads and/or targeting ligands. BIND’s collaboration with AstraZeneca has resulted in the Aurora B Kinase inhibitor ACCURIN AZD2811, which became the second ACCURIN candidate to enter clinical development. BIND’s collaboration with Pfizer has resulted in the selection of an ACCURIN candidate that is entering IND-enabling studies.
SOURCE: Bind Therapeutics
Post Views: 163
