Positive preclinical data of anti-tumor activity in melanoma xenograft model
Synergistic anti-tumor activity of OT-101, a TGF- β2inhibitor, and Dacarbazine against C8161 human melanoma xenograft in athymic nude mice
AGOURA HILLS, CA, USA I February 9, 2016 I Melanoma is the most aggressive and dangerous form of skin cancer in the United States. Transforming growth factor-beta 2 (TGF-β2) expression in malignant melanoma has been implicated in the development of deep invasion and metastases in malignant melanoma. OT-101, also known as Trabedersen, is a single-stranded 18-mer phosphorothioate antisense oligodeoxynucleotide designed to specifically target the human TGF-β2 messenger RNA. OT-101 had shown to inhibit the TGF-β2 secretion and proliferation of human malignant melanoma cell cultures (Mel-Juso, MER 116, and RPMI 7951) and cell migration from MER 116 spheroids. This study compared the antineoplastic potential of a novel treatment strategy combining OT-101 plus Dacarbazine (DTIC) versus DTIC monotreatment, the current chemotherapeutic mainstay in combating metastatic melanoma. Combining OT-101 and DTIC induced a synergistic effect on tumor inhibition in the C8161 melanoma model. Linear Regression model was created with two independent variables (OT-101 and DTIC) with an interaction variable. An equation was created: Y =1302.23 -30.39 (OT-101) -1018.56 (DTIC) -1197.59(OT-101)*(DTIC). The coefficient of interaction variable has same sign with two independent variable coefficients, which indicates a synergistic interaction effect (p
Poster Session
Meeting: The 10th Canadian Melanoma Conference, Whistler, British Columbia, Canada
Location: Fairmont Chateau Whistler
Date and Time: February19-20, 2016 9:05-9:20am
Title: ” Synergistic anti-tumor activity of OT-101, a TGF- β2 inhibitor, and Dacarbazine against C8161 human melanoma xenograft in athymic nude mice”.
Authors: Vuong Trieu*, Li Huang**, Osmond D’Cruz**, and Larn Hwang*
Institutions: ** Autotelic Inc, Fountain Valley, CA, United States and * Oncotelic Inc. Agoura Hills, CA, United States
About Trabedersen
Trabedersen, (OT-101) a single-stranded phosphorothioate antisense oligodeoxynucleotide (18-mer) designed to specifically target the human TGF-β2 messenger RNA. The Mechanism of Action exploration focuses on target downregulation and immunostimulation. Trabedersen is believed to reverse TGF-β’s immunosuppressive effects, rendering the tumor visible to a patient’s immune system and resulting in priming and specific activation of the patient’s anti-tumor immune response. Trabedersen has tested in Phase l/ll clinical trials against pancreatic cancer and melanoma. Trabedersen has also been tested in clinical trials against brain cancer.
About Oncotelic Inc.
Oncotelic’s lead therapeutic platform is OT-101 (Trabedersen). Oncotelic intends to conduct registration trials for multiple cancer indications including pancreatic, melanoma, and glioblastoma. The executives of Oncotelic are a group of pharmaceutical veterans who believe that Trabedersen will present a paradigm shift in the treatment of cancers. More information is available at www.oncotelic.com.
About Autotelic Inc.
Autotelic works through partners to transform how medications are being delivered. The Autotelic Inc. platform is aTherapeutic Drug Monitoring (TDM) device which allows PK guided dosing, reducing the toxicity from overmedication and increasing the efficacy from under-medication. Current dosing schemes result in either too much drug exposure or too little drug exposure because of individual pharmacokinetic variations. The Autotelic pipeline includes TDM devices for management of oncology, hypertension and pain. More information is available at www.autotelicinc.com.
SOURCE: Oncotelic
Post Views: 638
Positive preclinical data of anti-tumor activity in melanoma xenograft model
Synergistic anti-tumor activity of OT-101, a TGF- β2inhibitor, and Dacarbazine against C8161 human melanoma xenograft in athymic nude mice
AGOURA HILLS, CA, USA I February 9, 2016 I Melanoma is the most aggressive and dangerous form of skin cancer in the United States. Transforming growth factor-beta 2 (TGF-β2) expression in malignant melanoma has been implicated in the development of deep invasion and metastases in malignant melanoma. OT-101, also known as Trabedersen, is a single-stranded 18-mer phosphorothioate antisense oligodeoxynucleotide designed to specifically target the human TGF-β2 messenger RNA. OT-101 had shown to inhibit the TGF-β2 secretion and proliferation of human malignant melanoma cell cultures (Mel-Juso, MER 116, and RPMI 7951) and cell migration from MER 116 spheroids. This study compared the antineoplastic potential of a novel treatment strategy combining OT-101 plus Dacarbazine (DTIC) versus DTIC monotreatment, the current chemotherapeutic mainstay in combating metastatic melanoma. Combining OT-101 and DTIC induced a synergistic effect on tumor inhibition in the C8161 melanoma model. Linear Regression model was created with two independent variables (OT-101 and DTIC) with an interaction variable. An equation was created: Y =1302.23 -30.39 (OT-101) -1018.56 (DTIC) -1197.59(OT-101)*(DTIC). The coefficient of interaction variable has same sign with two independent variable coefficients, which indicates a synergistic interaction effect (p
Poster Session
Meeting: The 10th Canadian Melanoma Conference, Whistler, British Columbia, Canada
Location: Fairmont Chateau Whistler
Date and Time: February19-20, 2016 9:05-9:20am
Title: ” Synergistic anti-tumor activity of OT-101, a TGF- β2 inhibitor, and Dacarbazine against C8161 human melanoma xenograft in athymic nude mice”.
Authors: Vuong Trieu*, Li Huang**, Osmond D’Cruz**, and Larn Hwang*
Institutions: ** Autotelic Inc, Fountain Valley, CA, United States and * Oncotelic Inc. Agoura Hills, CA, United States
About Trabedersen
Trabedersen, (OT-101) a single-stranded phosphorothioate antisense oligodeoxynucleotide (18-mer) designed to specifically target the human TGF-β2 messenger RNA. The Mechanism of Action exploration focuses on target downregulation and immunostimulation. Trabedersen is believed to reverse TGF-β’s immunosuppressive effects, rendering the tumor visible to a patient’s immune system and resulting in priming and specific activation of the patient’s anti-tumor immune response. Trabedersen has tested in Phase l/ll clinical trials against pancreatic cancer and melanoma. Trabedersen has also been tested in clinical trials against brain cancer.
About Oncotelic Inc.
Oncotelic’s lead therapeutic platform is OT-101 (Trabedersen). Oncotelic intends to conduct registration trials for multiple cancer indications including pancreatic, melanoma, and glioblastoma. The executives of Oncotelic are a group of pharmaceutical veterans who believe that Trabedersen will present a paradigm shift in the treatment of cancers. More information is available at www.oncotelic.com.
About Autotelic Inc.
Autotelic works through partners to transform how medications are being delivered. The Autotelic Inc. platform is aTherapeutic Drug Monitoring (TDM) device which allows PK guided dosing, reducing the toxicity from overmedication and increasing the efficacy from under-medication. Current dosing schemes result in either too much drug exposure or too little drug exposure because of individual pharmacokinetic variations. The Autotelic pipeline includes TDM devices for management of oncology, hypertension and pain. More information is available at www.autotelicinc.com.
SOURCE: Oncotelic
Post Views: 638
