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A Vaxfectin(R)-formulated gB DNA vaccine induces antibodies that block cytomegalovirus entry into fibroblasts and epithelial cells in preclinical study
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Data presented at the 5th International Congenital CMV Conference in Brisbane, Australia
SAN DIEGO, CA, USA I April 21, 2015 I Vical Incorporated (VICL) today announced that Michael McVoy, Ph.D., Professor of Pediatrics at Virginia Commonwealth University, presented data from preclinical studies testing several combinations of Vaxfectin(R)– formulated glycoprotein-B (gB)-encoding DNA vaccines for neutralizing antibody responses. The data were featured at the 5th International Congenital CMV Conference held April 20-24, 2015, in Brisbane, Australia. Vaxfectin is Vical’s novel, proprietary cationic lipid-based adjuvant and is used in CyMVectin(TM), the company’s congenital CMV vaccine candidate. The studies found that vaccines encoding gB provided both fibroblast and epithelial entry neutralizing titers that were comparable to those observed in sera from humans with naturally-acquired CMV infections. The data suggest that CyMVectin has the potential to induce neutralizing antibodies against a broad range of cells.
“A vaccine to prevent birth defects caused by cytomegalovirus is a public health priority,” said Dr. Stuart Adler, M.D., Emeritus Professor, Department of Microbiology and Immunology, at Virginia Commonwealth University. “Accumulating evidence suggests that induction of antibodies that block viral entry into a broad range of cell types is an important determinant of vaccine efficacy. A gB DNA vaccine performs well in this regard, when compared with responses induced by natural infection. In addition, the simplicity of a single subunit delivered by DNA immunization is highly attractive compared with more complicated vaccines in development.”
“We believe that induction of both fibroblast and epithelial entry neutralizing antibodies is essential for providing protection against CMV,” said Larry Smith, PhD., Vical’s Vice President of Vaccine Research. “These findings support further development of CyMVectin for prevention of congenital CMV infections.”
About Congenital CMV
Currently, in the United States, approximately 40,000 children are born with a congenital CMV infection each year. Of these, about 4,000 have symptoms at birth and will have severe sequelae including deafness, mental impairment, and/or death. According to the National Cytomegalovirus Registry for Pregnant Women, congenital infection of a fetus usually occurs when a woman’s first CMV infection occurs during pregnancy. In the United States approximately 60% of pregnant women are seronegative and between 1% and 2% will have a primary CMV infection during pregnancy. The rate of CMV transmission to the fetus after a primary maternal infection during pregnancy is between 25% and 75% depending on gestational time of infection.
About Vical
Vical develops biopharmaceutical products for the prevention and treatment of chronic or life-threatening infectious diseases, based on its patented DNA delivery technologies and other therapeutic approaches. Additional information on Vical is available at www.vical.com.
SOURCE: Vical
Post Views: 230
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A Vaxfectin(R)-formulated gB DNA vaccine induces antibodies that block cytomegalovirus entry into fibroblasts and epithelial cells in preclinical study
-
Data presented at the 5th International Congenital CMV Conference in Brisbane, Australia
SAN DIEGO, CA, USA I April 21, 2015 I Vical Incorporated (VICL) today announced that Michael McVoy, Ph.D., Professor of Pediatrics at Virginia Commonwealth University, presented data from preclinical studies testing several combinations of Vaxfectin(R)– formulated glycoprotein-B (gB)-encoding DNA vaccines for neutralizing antibody responses. The data were featured at the 5th International Congenital CMV Conference held April 20-24, 2015, in Brisbane, Australia. Vaxfectin is Vical’s novel, proprietary cationic lipid-based adjuvant and is used in CyMVectin(TM), the company’s congenital CMV vaccine candidate. The studies found that vaccines encoding gB provided both fibroblast and epithelial entry neutralizing titers that were comparable to those observed in sera from humans with naturally-acquired CMV infections. The data suggest that CyMVectin has the potential to induce neutralizing antibodies against a broad range of cells.
“A vaccine to prevent birth defects caused by cytomegalovirus is a public health priority,” said Dr. Stuart Adler, M.D., Emeritus Professor, Department of Microbiology and Immunology, at Virginia Commonwealth University. “Accumulating evidence suggests that induction of antibodies that block viral entry into a broad range of cell types is an important determinant of vaccine efficacy. A gB DNA vaccine performs well in this regard, when compared with responses induced by natural infection. In addition, the simplicity of a single subunit delivered by DNA immunization is highly attractive compared with more complicated vaccines in development.”
“We believe that induction of both fibroblast and epithelial entry neutralizing antibodies is essential for providing protection against CMV,” said Larry Smith, PhD., Vical’s Vice President of Vaccine Research. “These findings support further development of CyMVectin for prevention of congenital CMV infections.”
About Congenital CMV
Currently, in the United States, approximately 40,000 children are born with a congenital CMV infection each year. Of these, about 4,000 have symptoms at birth and will have severe sequelae including deafness, mental impairment, and/or death. According to the National Cytomegalovirus Registry for Pregnant Women, congenital infection of a fetus usually occurs when a woman’s first CMV infection occurs during pregnancy. In the United States approximately 60% of pregnant women are seronegative and between 1% and 2% will have a primary CMV infection during pregnancy. The rate of CMV transmission to the fetus after a primary maternal infection during pregnancy is between 25% and 75% depending on gestational time of infection.
About Vical
Vical develops biopharmaceutical products for the prevention and treatment of chronic or life-threatening infectious diseases, based on its patented DNA delivery technologies and other therapeutic approaches. Additional information on Vical is available at www.vical.com.
SOURCE: Vical
Post Views: 230
