NEW YORK, NY, USA I December 18, 2013 I Retrophin, Inc. (OTCQB: RTRX) today announced its newest clinical development candidate RE-034 (cosyntropin), a long-acting synthetic analog (amino acids 1-24) of the naturally-occurring adrenocorticotropic hormone (ACTH) formulated with zinc. Cosyntropin is also known outside the U.S. as tetracosactide.
Retrophin plans to file an Investigational New Drug (IND) Application and initiate a Phase 1 pharmacokinetic trial of RE-034 in the first half of 2014. Shortly thereafter, the company plans to initiate Phase 3 pivotal clinical trials of RE-034 for the treatment of infantile spasms, or West Syndrome, a catastrophic form of epilepsy, and nephrotic syndrome, a devastating condition marked by very high levels of proteinuria. Commercially available ACTH formulations that are substantially similar to RE-034 have been shown to be efficacious in treating these diseases. Retrophin recently met with the U.S. Food and Drug Administration (FDA) and agreed with the FDA on a clinical trial design for approval in West Syndrome.
“Melanocortin agonists have shown profound activity in nephrology and neurology,” said Martin Shkreli, Founder and Chief Executive Officer of Retrophin. “These are two key therapeutic areas for Retrophin, so approximately a year ago we embarked on development of RE-034 and have recently reached major CMC milestones. Our planned robust clinical trials will add to the understanding of this class of compounds, and we look forward to exploring RE-034 as a treatment for additional grave diseases. Furthermore, our synthetic ACTH can potentially bring relief to the high cost burden associated with the currently available animal-derived formulation in the U.S.”
“This is promising news for patients who suffer from nephrotic syndrome and infantile spasms, two very serious conditions,” said Horacio Plotkin, M.D., Chief Medical Officer of Retrophin. “We expect that physicians would welcome the potential benefits and consistency of our compound, as synthetic medicines are often preferable to animal-derived drugs.”
Conference Call Information
Retrophin will host a conference call and webcast (with slides) tomorrow, Wednesday, Dec. 18, 2013, at 9:00 a.m. ET to discuss development plans for RE-034. To participate in the conference call, dial 1-800-591-6942 (U.S.) or 1-617-614-4909 (International), confirmation code 38074071, shortly before 9:00 a.m. tomorrow. The audio webcast and slides can be accessed at www.retrophin.com, in the Events and Presentations section. A replay of the call will be available from Wednesday, Dec. 18, 11:00 a.m. ET to Wednesday, Dec. 25, 11:59 p.m. ET. The replay number is 1-888-286-8010 (U.S.) or 1-617-801-6888 (International), confirmation code 18030776.
About Retrophin
Retrophin is a pharmaceutical company focused on the development, acquisition and commercialization of drugs for the treatment of serious, catastrophic or rare diseases for which there are currently no viable options for patients. The Company’s pipeline includes compounds for several catastrophic diseases, including Focal Segmental Glomerulosclerosis (FSGS), Pantothenate Kinase-Associated Neurodegeneration (PKAN), Duchenne Muscular Dystrophy and others. Retrophin’s lead compound, sparsentan, also known as RE-021, is scheduled to begin enrollment in a potentially pivotal Phase 2 clinical trial for FSGS during 2013. The Company intends to reintroduce Syntocinon Nasal Spray to assist initial postpartum milk ejection and also initiate clinical trials for the drug as a potential treatment for schizophrenia and autism. Retrophin plans to initiate a Phase 1 pharmacokinetic trial of RE-034, an ACTH analog, in the first half of 2014. For additional information, please visit www.retrophin.com.
SOURCE: Retrophin
Post Views: 247
NEW YORK, NY, USA I December 18, 2013 I Retrophin, Inc. (OTCQB: RTRX) today announced its newest clinical development candidate RE-034 (cosyntropin), a long-acting synthetic analog (amino acids 1-24) of the naturally-occurring adrenocorticotropic hormone (ACTH) formulated with zinc. Cosyntropin is also known outside the U.S. as tetracosactide.
Retrophin plans to file an Investigational New Drug (IND) Application and initiate a Phase 1 pharmacokinetic trial of RE-034 in the first half of 2014. Shortly thereafter, the company plans to initiate Phase 3 pivotal clinical trials of RE-034 for the treatment of infantile spasms, or West Syndrome, a catastrophic form of epilepsy, and nephrotic syndrome, a devastating condition marked by very high levels of proteinuria. Commercially available ACTH formulations that are substantially similar to RE-034 have been shown to be efficacious in treating these diseases. Retrophin recently met with the U.S. Food and Drug Administration (FDA) and agreed with the FDA on a clinical trial design for approval in West Syndrome.
“Melanocortin agonists have shown profound activity in nephrology and neurology,” said Martin Shkreli, Founder and Chief Executive Officer of Retrophin. “These are two key therapeutic areas for Retrophin, so approximately a year ago we embarked on development of RE-034 and have recently reached major CMC milestones. Our planned robust clinical trials will add to the understanding of this class of compounds, and we look forward to exploring RE-034 as a treatment for additional grave diseases. Furthermore, our synthetic ACTH can potentially bring relief to the high cost burden associated with the currently available animal-derived formulation in the U.S.”
“This is promising news for patients who suffer from nephrotic syndrome and infantile spasms, two very serious conditions,” said Horacio Plotkin, M.D., Chief Medical Officer of Retrophin. “We expect that physicians would welcome the potential benefits and consistency of our compound, as synthetic medicines are often preferable to animal-derived drugs.”
Conference Call Information
Retrophin will host a conference call and webcast (with slides) tomorrow, Wednesday, Dec. 18, 2013, at 9:00 a.m. ET to discuss development plans for RE-034. To participate in the conference call, dial 1-800-591-6942 (U.S.) or 1-617-614-4909 (International), confirmation code 38074071, shortly before 9:00 a.m. tomorrow. The audio webcast and slides can be accessed at www.retrophin.com, in the Events and Presentations section. A replay of the call will be available from Wednesday, Dec. 18, 11:00 a.m. ET to Wednesday, Dec. 25, 11:59 p.m. ET. The replay number is 1-888-286-8010 (U.S.) or 1-617-801-6888 (International), confirmation code 18030776.
About Retrophin
Retrophin is a pharmaceutical company focused on the development, acquisition and commercialization of drugs for the treatment of serious, catastrophic or rare diseases for which there are currently no viable options for patients. The Company’s pipeline includes compounds for several catastrophic diseases, including Focal Segmental Glomerulosclerosis (FSGS), Pantothenate Kinase-Associated Neurodegeneration (PKAN), Duchenne Muscular Dystrophy and others. Retrophin’s lead compound, sparsentan, also known as RE-021, is scheduled to begin enrollment in a potentially pivotal Phase 2 clinical trial for FSGS during 2013. The Company intends to reintroduce Syntocinon Nasal Spray to assist initial postpartum milk ejection and also initiate clinical trials for the drug as a potential treatment for schizophrenia and autism. Retrophin plans to initiate a Phase 1 pharmacokinetic trial of RE-034, an ACTH analog, in the first half of 2014. For additional information, please visit www.retrophin.com.
SOURCE: Retrophin
Post Views: 247
