- First data presentation on AGEN1571 shows strong adaptive and innate immune responses
- Preclinical data indicate superior performance to the only clinical-stage competitor
- Monotherapy activity and broad combination potential
- Investigational New Drug (IND) application cleared; clinical trial to commence
LEXINGTON, MA, USA I April 08, 2022 I Agenus Inc. (Nasdaq: AGEN), an immuno-oncology company with an extensive pipeline of therapeutics designed to activate immune response to cancers and infections, today announced the first presentation of preclinical data from AGEN1571 – a novel anti-ILT2 antibody designed to modulate tumor-associated macrophages, T, NK and NKT cells. These data are being presented at the American Association for Cancer Research (AACR) Annual Meeting being held April 8-12 in New Orleans, LA.
“The ILT receptor family represents a key suppressor of anti-tumor immunity that contributes to resistance to CTLA-4 and PD-1 directed therapies.” said Steven O’Day, MD, Chief Medical Officer of Agenus. “Blocking this receptor family offers the potential to overcome this resistance. This approach is validated by the durable clinical responses achieved in PD-1 resistant cancers with an ILT4 antagonist discovered by Agenus and licensed to Merck. AGEN1571 represents our first fully-owned clinical stage myeloid targeting agent.”
Presentation highlights:
- ILT2 offers a greater potential to overcome resistance to approved immunotherapies compared to ILT4. It provides a more prominent and broader expression profile across immune cell types in the tumor microenvironment.
- AGEN1571 demonstrates superior functional activity compared to the clinical-stage competitor with:
- ~10-fold higher binding affinity to all isoforms of ILT2, enabling superior binding to cells expressing low levels of ILT2
- Complete blockade of ILT2-ligand interactions for more effective immune activation and anti-tumor therapeutic potential
- Enhanced activation of T, NK, and NKT cells for improved tumor-killing
- Superior ability to switch myeloid cells to a pro-inflammatory state, which further boosts T and NK cell immunity
- Higher potency in boosting endogenous anti-tumor immunity to synergize with the patient’s anti-tumor antibodies or targeted therapies
- Combinations with botensilimab (Fc-enhanced CTLA-4) and other immuno-oncology agents lead to stronger immune cell activation
- IND application cleared by the FDA; clinical trial to commence
Presentation Details:
Abstract Title: AGEN1571 is a novel high-affinity ILT2 antagonist antibody that promotes adaptive and innate immune responses
Abstract Number: 2906 / 21
Session: Therapeutic Antibodies 2
Date / Time: April 12, 2022, 9:00 AM – 12:30 PM
Presenting Author: Olga Udartseva, PhD
The poster presentation can be accessed in the investor section of the Agenus website at https://investor.agenusbio.com/events-and-presentations.
About Agenus
Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body’s immune system to fight cancer. The Company’s vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its subsidiary MiNK Therapeutics), adjuvants, and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.
SOURCE: Agenus
Post Views: 157
- First data presentation on AGEN1571 shows strong adaptive and innate immune responses
- Preclinical data indicate superior performance to the only clinical-stage competitor
- Monotherapy activity and broad combination potential
- Investigational New Drug (IND) application cleared; clinical trial to commence
LEXINGTON, MA, USA I April 08, 2022 I Agenus Inc. (Nasdaq: AGEN), an immuno-oncology company with an extensive pipeline of therapeutics designed to activate immune response to cancers and infections, today announced the first presentation of preclinical data from AGEN1571 – a novel anti-ILT2 antibody designed to modulate tumor-associated macrophages, T, NK and NKT cells. These data are being presented at the American Association for Cancer Research (AACR) Annual Meeting being held April 8-12 in New Orleans, LA.
“The ILT receptor family represents a key suppressor of anti-tumor immunity that contributes to resistance to CTLA-4 and PD-1 directed therapies.” said Steven O’Day, MD, Chief Medical Officer of Agenus. “Blocking this receptor family offers the potential to overcome this resistance. This approach is validated by the durable clinical responses achieved in PD-1 resistant cancers with an ILT4 antagonist discovered by Agenus and licensed to Merck. AGEN1571 represents our first fully-owned clinical stage myeloid targeting agent.”
Presentation highlights:
- ILT2 offers a greater potential to overcome resistance to approved immunotherapies compared to ILT4. It provides a more prominent and broader expression profile across immune cell types in the tumor microenvironment.
- AGEN1571 demonstrates superior functional activity compared to the clinical-stage competitor with:
- ~10-fold higher binding affinity to all isoforms of ILT2, enabling superior binding to cells expressing low levels of ILT2
- Complete blockade of ILT2-ligand interactions for more effective immune activation and anti-tumor therapeutic potential
- Enhanced activation of T, NK, and NKT cells for improved tumor-killing
- Superior ability to switch myeloid cells to a pro-inflammatory state, which further boosts T and NK cell immunity
- Higher potency in boosting endogenous anti-tumor immunity to synergize with the patient’s anti-tumor antibodies or targeted therapies
- Combinations with botensilimab (Fc-enhanced CTLA-4) and other immuno-oncology agents lead to stronger immune cell activation
- IND application cleared by the FDA; clinical trial to commence
Presentation Details:
Abstract Title: AGEN1571 is a novel high-affinity ILT2 antagonist antibody that promotes adaptive and innate immune responses
Abstract Number: 2906 / 21
Session: Therapeutic Antibodies 2
Date / Time: April 12, 2022, 9:00 AM – 12:30 PM
Presenting Author: Olga Udartseva, PhD
The poster presentation can be accessed in the investor section of the Agenus website at https://investor.agenusbio.com/events-and-presentations.
About Agenus
Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body’s immune system to fight cancer. The Company’s vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its subsidiary MiNK Therapeutics), adjuvants, and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.
SOURCE: Agenus
Post Views: 157
