B-Cell Maturation Antigen (BCMA): hot target for emerging treatment modalities

Publisher: La Merie Publishing
Pages: 39
Format: PDF
Product Line:
Brief Report
Product Code: LMBR0012
Release Date: August of 2016

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B-Cell Maturation Antigen (BCMA): hot target for emerging treatment modalities

The highly restricted expression of B-cell maturation antigen (BCMA) to plasma cells and its role in the survival and growth for multiple myeloma cells makes BCMA a good potential target for enhanced immunotherapeutic strategies. This report describes and analyzes the

  • Scientific rationale for BCMA-targeted therapies;
  • Preclinical proof-of-concept of BCMA blockade;
  • Clinical experience with BCMA-targeted therapies;
  • The competitive landscape of BCMA-targeted treatment modalities;
  • Profiles of anti-BCMA CAR T-cells, antibody-drug conjugate and T-cell redirecting bispecific antibodies:
  • Profiles of companies involved in develompent of anti-BCMA therapy candidates.

Especially activity-enhanced antibodies and cells such as antibody-drug conjugates (ADCs) and T-cell redirecting bispecific antibodies as well as chimeric antigen receptor (CAR) T-cells, respectively, will benefit from the high target selectivity of BCMA to avoid on-target, off-tumor toxicity. As a consequence, novel cellular and humoral BCMA-targeted treatment modalities have emerged and resulting product candidates entered first-in-human clinical evaluation. Further development candidates are undergoing IND-enabling studies.



B-Cell Maturation Antigen (BCMA): hot target for emerging treatment modalities

Table of Contents

1          Target Background

2          Target Antigen Expression Profile

3          Preclinical Proof-of-Concept

4          Clinical Indications & Treatment Options

5          Clinical Experience with BCMA-Targeted Treatment Modalities

6          Treatment Modalities & Competitive Landscape

7          Drug & Cell Therapy Candidate Profiles
7.1       CAR T-Cells
7.2       Antibody-Drug Conjugate (ADC)
7.3       T-Cell Redirecting Antibodies

8          Company Profiles

9          References


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