Agenus Presents Clinical Responses of AGEN1884 (anti-CTLA-4) and AGEN2034 (anti-PD-1) at ASCO 2018

- AGEN1884 and AGEN2034 produce clinical benefit2 in 31% and 42% of patients respectively

- Combination trial of AGEN1884 plus AGEN2034 in 2L cervical cancer ongoing to support BLA

LEXINGTON, MA, USA I June 4, 2018 I Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with a pipeline of immune checkpoint antibodies, cancer vaccines, and adoptive cell therapies1, today presented updated clinical data on its lead CTLA-4 and PD-1 programs at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, in Chicago.  Agenus is expanding beyond these backbone I-O compounds with 6 planned INDs in 2018 and 2 additional INDs in 1H2019.

Over 100 patients with advanced refractory cancer received CTLA-4 (AGEN1884) and/or PD-1 (AGEN2034). Clinical benefit was observed in 31% and 42% of evaluable patients, respectively.  Both antibodies were well tolerated with prolonged exposure and the recommended dose was selected for the ongoing phase 2 trial of combination AGEN1884 (1mg/kg) and AGEN2034 (3mg/kg) in 2L cervical cancer. The pharmacology and half-life of AGEN1884 and AGEN2034 are comparable to commercially available CTLA-4 and PD-1.   

"CTLA-4 and PD-1 are backbone I-O therapies, critical drivers of efficacy in combination with each other and standard of care treatments.  Our CTLA-4 (of the same IgG1 subclass as Yervoy®) PD-1 are the most advanced clinical stage combination," said Garo Armen, Ph.D., Chairman and CEO of Agenus.  "Expanding from here, we are on track to file 6 INDs this year which includes bispecific antibodies that modify the tumor microenvironment to make tumors more susceptible to immune attack. These next gen compounds are amongst the most desirable approaches and we have at least two compounds with these properties as well as a next generation CTLA-4 (AGEN1181), designed to enhance T cell priming."

ASCO posters are available on the Company's website at http://agenusbio.com/technology/publications/.

About Agenus
Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support early phase clinical programs. Agenus is headquartered in Lexington, MA.  For more information, please visit www.agenusbio.com; information that may be important to investors will be routinely posted on our website.

1Through AgenTus Therapeutics, a subsidiary of Agenus
2Clinical benefit is defined as partial responses, complete responses, disease stabilization; observed in 5 of 16 evaluable patients for CTLA-4 and 13 of 31 evaluable patients for PD-1

SOURCE: Agenus

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